Comparison of the effect Xuezhikang and simvastatin on cholesterol absorption and synthesis markers in patients with coronary artery disease
Abstract：Objective To compare the effect of Xuezhikang and simvastatin on cholesterol absorption and synthesis markers in patients with coronary artery disease.Methods Sixty-five consecutive patients with coronary artery disease confirmed by coronary angiography from January 2014 to September 2015 were randomly divided into Xuezhikang group (31 cases) given Xuezhikang 1.2g/d and simvastatin group given simvastatin 20mg/d for 12 weeks.The blood lipid [total cholesterol (TC),triglyceride,high density lipoprotein-cholesterol (HDL-C)and low density lipoprotein-cholesterol (LDL-C)],cholesterol synthesis markers (squalene,lanthosterol and desmosterol) cholesterol absorption markers (campesterol,stigmasterol and sitosterol) before treatment and 4,12 weeks after treatment were compared between groups.Results After 4 and 12 weeks of treatment,the levels of TC,LDL-C and lanthosterol were significantly decreased,the level of sitosterol was significantly increased compared with those before treatment in simvastatin group [(3.75 ±0.24),(3.76 ±0.32) mmol/L vs (4.74 ±0.54) mmol/L;(2.46±0.18),(2.51 ±0.08) mmoL/L vs (3.39 ±0.26) mmol/L;(6.01 ±0.54),(6.03 ±0.24) mg/L vs (7.30±0.82) mg/L;(15.4±0.9),(15.7 ±1.3) mg/L vs (14.5±1.0) mg/L] (P＜0.05).After 4 and 12 weeks of treatment,the levels of TC,LDL-C,lanthosterol and sitosterol were all significantly decreased compared with those before treatment in Xuezhikang group [(3.80 ± 0.22),(3.78 ±0.19) mmol/L vs (4.68 ±0.25) mmol/L;(2.61 ±O.20),(2.57 ±0.16) mmol/L vs (3.33 ±0.22) mmol/L;(6.26±0.38),(6.42±0.21) mg/L vs (7.01 ±0.31) mg/L;(14.1 ±1.0),(13.8 ±0.6) mg/L vs (15.1 ±0.7) mg/L] (P ＜ 0.05).After 12 weeks,the blood lipid and cholesterol metabolism markers were not significantly changed compared with those after 4 weeks (P ＞ 0.05).Conclusions Simvastatin can inhibit the cholesterol synthesis,while not compensatively increase the cholesterol absorption;Xuezhikang can markedly decrease both cholesterol absorption and synthesis,being more comprehensive and reasonable.
Keywords：Coronary artery diseaseCholesterol metabolism markerXuezhikangSimvastatin
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 984-987 )