Effect of trimetazidine on short-term cardiac function in acute ST-elevation myocardial infarction patients after emergency percutaneous coronary intervention
Li Yuanzheng
Wang Lizhong
Dong Peng
Liu Fang
Jiang Yang
Li Yinhua
Abstract：Objective To investigate the effect of trimetazidine on short-term cardiac function in acute ST-elevation myocardial infarction (STEMI) patients after emergency percutaneous coronary intervention (PCI).Methods Totally 75 STEMI patients after PCI with Thrombolysis In Myocardial Infarction coronary flow grade 3 were consecutively enrolled from November 2013 to November 2015 in Aviation General Hospital and Daxing Hospital,Capital Medical University.All patients were randomly divided into control group,low dose trimetazidine group and high dose trimetazidine group,each group had 25 cases.All 3 groups were given routine secondary prevention treatment of coronary heart disease after PCI,low and high dose trimetazidine groups were respectively added trimetazidine 20mg/time and 40mg/time,3times/d orally.Plasma amino-terminal pro-brain natriuretic peptide(N-proBNP),left ventricular end-diastolic dimension (LVEDD)and left ventricular ejection fraction (LVEF) at 1 week,1 month and 3 months after PCI were analyzed.Results At 1 week after PCI,plasma levels of N-proBNP in low and high dose trimetazidine groups were significantly lower than control group[(986 ± 403),(895 ± 387)ng/L vs (1453 ± 428)ng/L] (P ＜ 0.05);the difference of N-proBNP between 2 trimetazidine groups and differences of LVEF,LVEDD among 3 groups were not significant(P ＞0.05).At 1 month and 3 months after PCI,plasma levels of N-proBNP had no significant differences among 3 groups (P ＞ 0.05);LVEDD was significantly lower and LVEF was significantly higher in low and high trimetazidine groups than control group[(52 ± 4),(51 ±4)mm vs(58 ±4)mm;(52 ±3),(49 ±4)mm vs(58 ±4)mm;(53 ±5)％,(54 ±6)％ vs(46 ±6)％;(54 ± 5) ％,(55 ± 5) ％ vs(46 ± 5) ％] (all P ＜ 0.05);differences of LVEF and LVEDD between 2 trimetazidine groups were not significant (P ＞ 0.05).Conclusion Trimetazidine can help the improvement of short-term cardiac function for STEMI patients after emergency PCI.
Keywords：Acute myocardial infarctionTrimetazidinePercutaneous coronary interventionCardiac function
Publication Date：2016-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 954-957 )