Effect of sufentanil combined with dexmedetomidine on postoperative analgesia in patients undergoing thoracotomy surgeries

Yang Wenrong; Ding Zejun; Yang Hongguang; Ai Dengbin

doi:10.3760/cma.j.issn.1673-4777.2016.06.020

Abstract：Objective To observe the effect of sufentanil combined with dexmedetomidine on postoperative analgesia in patients undergoing thoracotomy surgeries.Methods Sixty patients undergoing elective gynecological laparoscopic surgeries from March 2014 to March 2015 were randomly divided into sufentanil group (30 cases) receiving patient controlled intravenous analgesia (PCIA) with sufentanil 1.0 lag/(kg · d),combined group (30 cases) receiving PCIA with sufentanil 1.0 μg/(kg · d) + dexmedetomidine 1.0 μg/(kg· d).The pain intensity was assessed with visual analog scale (VAS) immediately after operation (T1) and 2 h (T2),4 h (T3),6 h (T4),12 h (T5),24 h (T6),48 h (T7) after operation.The number of self-controlled press of the pump and incidence of side effects were recorded.Results The VAS score at all the time points were less than 4 scores in both groups;at T2-T7 time point,the VAS score in sufentanil group was significantly higher than that in combined group [(2.10 ± 1.55) scores vs (0.86 ±0.80) scores,(1.89 ± 1.36) scores vs (0.75 ±0.48) scores,(1.65 ± 1.27) scores vs (0.68 ± 0.57) scores,(1.62 ± 1.18) scores vs (0.50 ± 0.39) scores,(1.60 ± 1.06) scores vs (0.47 ± 0.31) scores,(0.60 ± 0.18) scores vs (0.00 ± 0.00) scores] (P ＜ 0.05).At T2-T7 time point,the number of self-controlled press of the pump in sufentanil group was significantly more than that in combined group [(16.0 ± 2.8) times vs (6.8 ± 2.7) times,(86 ± 10) μg vs (68 ± 7) μg] (P ＜ 0.05).The incidence of nausea and vomiting in sufentanil group was significantly higher than that in combined group [33.3％ (10/30) vs 0.0％ (0/30)] (P ＜0.05).Conclusion Dexmedetomidine can reduce the postoperative consumption of sufentanil in patients undergoing thoracotomy surgeries,and decrease the incidence of nausea and vomiting.