Correlations of polymorphisms of Toll-like receptor 1 and helicobacter pylori infection with gastric cancer
Mu Chongyun
Qin Kaikai
Jiang Xiangjun
Abstract：Objective To investigate the correlations of polymorphisms of Toll-like receptor 1 (TLR1),helicobacter pylori(Hp).Methods Totally 225 patients with gastric carcinoma diagnosed for the first time (observation group) and 225 patients with chronic gastritis (control group) from January 2013 to December 2014 were enrolled.The rs4833095 polymorphisms of TLR1 were genotyped by the gene sequencing.The correlations of polymorphisms of TLR1,Hp infection and gastric cancer were analyzed after adjusting the age,gender,Hp infection with multiariable Logistic regression models.Results The frequencies of GG,AG and AA genotype on TLR1 rs4833095 were 33.8％ (76/225),49.8％ (112/225) and 16.4％ (37/225) in observation group,43.6％ (98/225),48.0％ (108/225) and 8.4％ (19/225) in control group,they were significantly different between groups (x2 =8.64,P =0.013).Compared with GG genotype carriers,GA + AA genotype carriers had significantly higher risk of gastric cancer (odds ratio =1.42,95％ confidence interval:0.96-2.13).Joint effect analysis showed that compared with GG genotype carriers without Hp infection,GA + AA genotype carriers with Hp infection had significantly higher risk of gastric cancer (odds ratio =2.23,95％ confidence interval:1.28-3.86).Conclusion Polymorphism of TLR1 rs4833095 is correlated with gastric cancer,a alleles have increased susceptibility to gastric cancer.
Keywords：Gastric cancerToll-like receptor 1PolymorphismHelicobacter pylori
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 848-852 )