Effect of indomethacin in preventing post-endoscopic retrograde cannulation pancreatitis in patients undergoing common bile duct cholecystolithotomy
Zhai Lili
Huang Kun
Yu Jiufei
Abstract：Objective To investigate the effect of indomethacin in preventing post-endoscopic retrograde cannulation (ERCP) pancreatitis (PEP) in patients undergoing common bile duct cholecystolithotomy.Methods Totally 51 patients with common bile duct stones who underwent ERCP common bile duct cholecystolithotomy from January 2014 to December 2014 were randomly divided into indomethacin group (26 cases) and control group (25 cases).Indomethacin group was rectally administrated with indomethacin (100 mg) 60 min before operation and control group was not given indomethacin.The serum amylase was detected 2,6 and 24 h after operation,the incidences of PEP and postoperative hyperamylasemia were compared between groups.Results The serum amylase level in indomethacin group was significantly lower than that in control group 6 and 24hafterERCP [(202±41) U/Lvs (409 ±77) U/L,(111±18) U/L vs (264 ±56) U/L] (P＜0.05),while it was not significantly different between indomethacin group and control group 2 h after ERCP [(128 ± 20) U/L vs (192 ± 29) U/L] (P ＞0.05).Totally 16.0％ (4/25) in control group and 0.0％ (0/26) in indomethacin group had PEP,48.0％ (12/25) in control group and 26.9％ (7/26) in indomethacin group had hyperamylasemia,both being significantly different between groups (P ＜ 0.05).Conclusion Rectal administration of indomethacin can prevent PEP and postoperative hyperamylasemia in patients who underwent ERCP common bile duct stone cholecystolithotomy.
Keywords：PancreatitisIndomethacinEndoscopic retrograde cannulation of the pancreaticHyperamylasemia
Publication Date：2016-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 836-838 )