Clinical analysis of 143 patients with drug-induced liver injury
Lu Lu
Wang Qinying
Abstract：Objective To explore the clinical features of patients with drug-induced liver injury and the influence factors of prognosis.Methods Totally 143 patients diagnosed as drug-induced liver injury from October 2013 to October 2015 were enrolled,and the general information,medication history,onset time,hepatic function,basic disease,treatment and prognosis were retrospectively analyzed.Results In 143 patients,there were 49 males and 94 females,the age was 9-76 years [(44 ±7) years].The drug-induced liver injury was mainly caused by cardiovascular disease medication [18.2％ (26/143)],followed by skin disease medication [11.9％ (17/143)] and thyroid disease medication [11.2％ (16/143)].The time of onset was mostly 1 week to 1 month after medication [32.9％ (47/143)],followed by 1-3 months after medication [21.7％ (31/143)] and more than 12 months after medication [21.0％ (30/143)];the treatment efficiency was not significantly different among groups of different onset time (x2 =1.43,P ＞ 0.05).Liver cell injury is the most common injury type [49.7 ％ (71 / 143)],followed by hybrid injury [37.1％ (53/143)] and cholestasis injury [13.3 ％ (19/143)];the treatment efficiency was not significantly different among groups of different injury types (x2 =1.42,P ＞ 0.05).The levels of total bilirubin and alkaline phosphatase in non-responders were significantly higher than those in patients with good treatment efficiency [(257 ± 81) μmol/L vs (81 ± 37) μmol/L,(212 ± 99) U/L vs (125 ±40) U/L] (P ＜0.05).Conclusion The incidence of drug-induced liver injury mainly injury type is liver cell injury;the levels of total bilirubin and alkaline phosphatase can be used as a predictive factor of prognosis.
Keywords：Drug-induced liver injuryClinical featurePrognosis
Publication Date：2016-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 833-835 )