Effect of ezetimibe combined with rosuvastatin in treating type 2 diabetes mellitus complicated with hyperlipidemia
Abstract：Objective To explore the effect of ezetimibe combined with rosuvastatin in treating type 2 diabetes mellitus complicated with hyperlipidemia.Methods Totally 140 cases with type 2 diabetes mellitus complicated with hyperlipidemia from June 2013 to June 2014 were randomly divided into observation group and control group (70 cases in each group).Both groups received conventional treatment;control group was added rosuvastatin (10 mg,l time/d,orally);observation group was added rosuvastatin (10 mg,1 time/d,orally) and ezetimibe (10 mg,1 time/d,orally).The treatment lasted for 3 months.The levels of fasting insulin,fasting glucose,glycosylated hemoglobin,triacylglycerol,total cholesterol,low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) before and after treatment.The ratios of cases with LDL-C ＜ 4.14 mmol/L and ＜ 3.37 mmol/L and the incidence of adverse reactions were recorded.Results The levels of fasting insulin,fasting glucose,glycosylated hemoglobin,total cholesterol,triacylglycerol,LDL-C,HDL-C,ratios of cases with LDL-C ＜ 4.14 mmol/L and ＜ 3.37 mmol/L before treatment were not significantly different between groups (P ＞ 0.05).After treatment,the levels of total cholesterol,triacylglycerol,LDL-C were significantly decreased in both groups,and were significantly lower in observation group than those in control group [(3.5 ± 0.7) mmol/L vs (4.2±0.6) mmol/L,(1.28 ±0.12) mmol/L vs (1.49±0.14) mmol/L,(3.2 ±0.6) mmol/L vs (4.0 ± 0.8) mmol/L],the ratios of cases with LDL-C ＜ 4.14 mmol/L and ＜ 3.37 mmol/L were significantly increased,and were significantly higher in observation than those in control group [62.9％ (44/70) vs 28.6％ (20/70),90.0％ (63/70)vs67.1％ (47/70)] (P＜0.05).The levels of alanine aminotransferase,aspartate aminotransferase,creatine kinase and incidence of gastrointestinal reaction before and after treatment were not significantly different between groups (P ＞ 0.05).Conclusion Ezetimibe combined with rosuvastatin has better effect compared with single rosuvastatin in treating type 2 diabetes mellitus complicated with hyperlipidemia
Keywords：Diabetes mellitus,type 2HyperlipidemiaEzetimibeRosuvastatin
Publication Date：2016-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 821-824 )