Analysis of endothelin-1 and urinary microalbumin in patients with obstructive sleep apnea hypopnea syndrome
Xin Qinghong
Abstract：Objective To analyze the levels of endothelin-1 and urinary microalbumin in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Totally 45 patients with OSAHS from August 2013 to February 2015 were enrolled (observation group);at the same period,45 healthy subjects were selected as control group.The levels of endothelin-1 and urinary microalbumin,the hypopnea index (AHI),the lowest oxygen saturation (LSaO2) were compared between groups;the correlations among them were analyzed.Results The levels of endothelin-1 and urinary microalbumin in observation group were significantly higher than those in control group [(78 ± 12) ng/L vs (30 ± 10) ng/L,(456 ± 57) mg/L vs (56 ± 7) mg/L] (P ＜ 0.05).The AHI was significantly higher,the LSaO2 was significantly lower in observation group than those in control group [(31.9 ± 3.3) times/h vs (3.3 ± 2.9) times/h,(60.3 ± 3.1) ％ vs (84.7 ± 2.0) ％] (all P ＜ 0.05).Correlation analysis showed that endothelin-1 and urinary microalbumin were positively correlated with AHI (r =0.483,0.445,both P ＜ 0.05),were negatively correlated with LSaO2 (r =-0.395,-0.436,all P ＜ 0.05).Multivariate logistic regression analysis showed that endothelin-1 and urinary microalbumin were the independent risk factors of OSAHS (odds ratio =3.287,7.873,both P ＜ 0.05).Conclusion The levels of endothelin-1 and urinary microalbumin increase in OSAHS patients and are independent risk factors OSAHS.
Keywords：Obstructive sleep apnea hypopnea syndromeEndothelin-1Urinary microalbuminCorrelation
Publication Date：2016-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 812-815 )