Effect of preoperative FOLFOX chemotherapy combined with radiotherapy in patients with locally advanced rectal cancer undergoing single-port access laparoscopic abdominoperineal resection for anus and rectum under jackknife position
Su Jiaqing
Bi Jianwei
Abstract：Objective To explore the effect of preoperative FOLFOX chemotherapy combined with radiotherapy in patients with locally advanced rectal cancer who underwent single-port access laparoscopic abdominoperineal resection for anus and rectum (Miles surgery) under jackknife position.Methods Totally 136 patients with locally advanced rectal cancer who underwent single-port access laparoscopic abdominoperineal resection for anus and rectum (Miles surgery) under jackknife position from March 2009 to May 2012 were randomly divided into observation group and control group (68 cases in each group).Preoperative FOLFOX chemotherapy combined with radiotherapy was given in observation group and single radiotherapy was given in control group.The visual analog scale (VAS) score before chemotherapy combined with radiotherapy (or radiotherapy) and after surgery,short-term and long term curative effect,adverse reaction were compared between groups.Results The VAS scores before chemotherapy combined with radiotherapy (or radiotherapy) and after surgery,the remission rate of pain 1 month after surgery were not significantly different between groups (P ＞ 0.05).One month after operation,the effective rate in observation group was significantly higher than that in control group [64.7％ (44/68) vs 38.2％ (26/68)] (P =0.022).The incidence of adverse reactions was not significantly different between groups (P ＞ 0.05).The 1-and 2-year survival rate in observation group was significantly higher than those in control group [81.4％ vs 50.0％,65.1％ vs 25.6％] (both P ＜ 0.01);the 3-year survival rate was not significantly different between groups (11.8％ vs 10.3％) (P =0.78).Conclusion In Single-port access laparoscopic Miles surgery under jackknife position,preoperative FOLFOX chemotherapy combined with radiotherapy can improve the short-term effect,1-and 2-year survival rate compared with preoperative single radiotherapy in patients with locally advanced rectal cancer.
Keywords：Rectal tumor,advancedAbdominoperineal resection for anus and rectumJackknife positionSingle-port access laparoscopicFOLFOX chemotherapy
Publication Date：2016-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 694-697 )