Effect and safety of oxiracetam in treating vascular cognitive impairment
Zhang Wei
Zhang Linhong
Zhang Mei
Ye Fei
Zhang Li
Abstract：Objective To evaluate the curative effect and safety of oxiracetam in treating vascular cognitive impairment (VCI).Methods Totally 88 VCI patients from February 2012 to August 2013 were randomly divided into control group (44 cases) and observation group (44 cases).Control group was given routine treatment and observation group was administered with oxiracetam (800 mg/time,3 times/d,oral) on the basis of routine treatment;the treatment lasted for 12 weeks.The mini mental state examination (MMSE),Clinical Dementia Rating (CDR),barthel index (BI) and national institute of health stroke scale (NIHSS) were used to assess the curative effect;the adverse reactions during treatment were recorded.Results The scores of MMSE,CDR,BI and NIHSS before treatment were not significantly different between groups (P ＞ 0.05).After treatment,all the scores were improved in both groups (P ＜ 0.05),in addition,the scores of MMSE,BI were significantly higher than,the scores of CDR and NIHSS were significantly lower than in observation group that those in control group [(23 ± 5) scores vs (20 ± 3) scores,(76 ± 5) scores vs (71 ± 6) scores,(1.36 ± 0.26) scoresvs (1.62 ±0.29) scores,(16 ±5) scores vs (19 ±5) scores] (P＜0.05).Two cases in observation group had mild gastrointestinal reactions,all the other patients showed no adverse reactions.Conclusion Oxiracetam has good curative effect in treating vascular cognitive impairment,and the safety is good.
Keywords：Cognitive disorderOxiracetamCurative effect
Publication Date：2016-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 675-679 )