Analysis of prognosis influence factors in patients with cerebral hemorrhage in acute stage

Wei Na; Han Yanyan

doi:10.3760/cma.j.issn.1673-4777.2016.05.012

Abstract：Objective To explore the clinical value of biochemical indexes in patients with cerebral hemorrhage in acute stage.Methods Totally 90 cases with acute cerebral hemorrhage from February 2011 to February 2013 were enrolled and divided into poor prognosis group (14 cases) and good prognosis group (76 cases).The general information and serum biochemical indexes including lipoprotein (a),blood glucose,high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),triacylglycerol,total cholesterol,blood uric acid,homocysteine (Hcy),high-sensitivity C-reactive protein (hs-CRP),serum creatinine were measured and compared between groups.The prognostic factors were analyzed by multiple Logistic regression analysis.Results The age,blood glucose,HDL-C,blood uric acid,hs-CRP,serum creatinine in poor prognosis group were significantly higher than those in good prognosis group [(72 ± 14) years vs (65 ± 11) years,(8.9 ±3.8) mmol/L vs (7.0 ±2.1) mmol/L,(1.6 ±0.5) mmo]/L vs (1.3 ±0.4) mmol/L,(371 ±123) μ mol/L vs (305±104) μmol/L,(14.9±2.5) mg/Lvs (6.6±1.7) mg/L,(136±43) μmol/L vs (113±23) μmol/L](P ＜0.05).The lipoprotein (a),LDL-C,triacylglycerol,total cholesterol,Hcy,hs-CRP were not significantlydifferent between groups [(260 ± 137) mg/L vs (253 ± 117) mg/L,(2.7 ± 1.1) mmol/L vs (2.7 ±0.9) mmol/L,(1.5 ± 1.3) mmol/L vs (1.5 ± 0.9) mmol/L,(4.9 ± 1.1) mmol/L vs (4.8 ± 1.0) mmol/L,(11 ± 7) μmol/L vs (12 ± 6) μmol/L,(1.27 ± 0.32) mg/L vs (1.19 ± 0.28) mg/L] (P ＞ 0.05).Multiple Logistic regression analysis showed that hs-CRP,HDL-C,blood glucose,serum creatinine,blood uric acid,age were correlated to prognosis (odds ratio =3.28,2.07,1.31,1.11,1.08,1.04,all P ＜0.05).Conclusion Hs-CRP,HDL-C,blood glucose,serum creatinine,blood uric acid and age are risk factors of poor prognosis in patients with intracerebral hemorrhage in acute stage.