Clinical effect of omeprazole combined with domperidone in treating obstructive sleep apnea-hypopnea syndrome complicated with laryngopharyngeal reflux disease
Zhang Ping
Rao Yuansheng
Zhang Lichuan
Yan Xiaojuan
Han Yang
Yan Suying
Abstract：Objective To explore the clinical effect of omeprazole combined with domperidone in treating obstructive sleep apnea-hypopnea syndrome (OSAHS) complicated with laryngopharyngeal reflux disease (LPRD).Methods Totally 51 OSAHS patients complicated with LPRD from May 2013 to May 2015 were treated with omeprazole enteric capsules (20 mg,2 times/d) and domperidone (10 mg,3 times/d) for 8 weeks.The reflux symptom index score (RSI) and reflux finding score (RFS) were measured before,2,4 and 8 weeks after treatment;polysomnography was performed before and 8 weeks after treatment.Results After 2 and 4 weeks of treatment,the proportions of patients with RSI ＞ 13 scores and RFS ＞ 7 scores were not significantly changed compared with those before treatment (P ＞ 0.05);after 8 weeks of treatment,the proportions of patients with RSI ＞ 13 scores and RFS ＞7 scores were significantly lower than those before treatment [9.8％ (5/51) vs 88.2％ (45/51),9.8％ (5/51) vs 92.2％ (47/51)] (P ＜0.05).Eight weeks after treatment,polysomnography monitoring showed that the sleep structure was significantly improved,showing as followed:the proportion of Ⅰ period sleep was significantly lower,the proportions of Ⅲ period sleep and rapid eye movement sleep were significantly higher than those before treatment [(12.2 ± 2.2) ％ vs (15.5 ± 3.2) ％,(4.7 ± 0.4) ％ vs (2.5 ± 0.3) ％,(26.7 ± 7.8) ％ vs (23.8 ± 8.7) ％],in addition,the apnea hypopnea index,hypopnea index,micro arousals were significantly lower than those before treatment [(38 ± 10) times/h vs (46 ± 12) times/h,(9 ±4) times/h vs (14 ±6) times/h,(22 ±9) times/h vs (35 ± 12) times/h] (P ＜0.05).Conclusion Omeprazole combined with domperidone can effectively relieve symptoms and signs in OSAHS patients complicated with LPRD and improve the quality of sleep.
Keywords：Obstructive sleep apnea-hypopnea syndromeLaryngopharyngeal reflux diseaseOmeprazoleDomperidone
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 667-671 )