Effect of dexmedetomidine on hemodynamics during intubation of double lumen endobronchial tube in elderly patients with hypertension
Zhai Wenting
Liu Wei
Geng Wanming
Abstract：Objective To investigate the influence of dexmedetomidine on hemodynamics during intubation of double lumen endobronchial tube in elderly patients with hypertension.Methods Sixty elderly patients with hypertension who underwent thoracotomy operation from May 2014 to March 2015 were randomly divided into control group (30 cases) and observation group (30 cases).Dexmedetomidine (0.5 μg/kg,4 mg/L) and the 0.9％ sodium chloride (the same dose) were respectively intravenously infused within 20 min before anesthesia induction in observation group and control group.The mean arterial pressure (MAP),heart rate (HR),bispectral index (BIS) immediately after admission (T1),10 and 20 min after infusion of dexmedetomidine or 0.9％ sodium chloride (T2,T3),before intubation (T4),intubation (T5),1,3,5 min after intubation (T6,T7,T8) were recorded;the concentration of epinephrine (E) and norepinephrine (NE) in blood were monitored at T4-T8;the usage of propofol during anesthesia induction was recorded.Results At T1,T2,the MAP and HR were not significantly different between groups (P ＞ 0.05).The MAP and HR at T3,T5-T8,the BIS at T3 in observation group were significantly lower than those in control group [MAP:(80 ± 14) mmHg vs (98 ± 15) mmHg,(96 ±18) mmHgvs (116±14) mmHg,(110±10) mmHg vs (130±12) mmHg,(104±11) mmHg vs (126±10) mmHg,(100 ± 12) mmHg vs (120 ± 14) mmHg;HR:(65 ± 10) times/min vs (77 ± 14) times/min,(68 ± 10) times/min vs (88 ± 12) times/min,(80 ± 11) times/min vs (98 ± 14) times/min,(77 ± 16) times/min vs (90 ± 13) times/min,(70 ± 11) times/min vs (88 ± 15) times/min;BIS:(80 ± 6) vs (93 ± 7)] (P ＜ 0.05).At T5-T8,the levels of E and NE in observation group were significantly lower than those in control group [E:(40±10) nmol/Lvs (51 ±12) nmol/L,(50±11) nmol/Lvs (64±9) nmol/L,(49±11) nmol/Lvs (60 ± 10) nmol/L,(44 ± 10) nmol/L vs (55 ± 11) nmol/L;NE:(101 ± 14) nmol/L vs (136 ± 13) nmol/L,(123 ± 17) nmol/L vs (158 ± 15) nmol/L,(109 ± 16) nmol/L vs (147 ± 14) nmol/L,(102 ± 18) nmol/L vs (116 ± 19) nmol/L] (P ＜ 0.05).The usage of propofol in observation group were significantly less than that in control group [(84 ±26)mg vs (108 ±30)mg] (P＜0.05).Conclusion Use of 0.5 μg/kg dexmedetomidine can reduce stress reaction to intubation of double lumen endobronchial tube and stabilize the hemodynamics inelderly patients with hypertension.
Keywords：HypertensionDexmedetomidineIntubationHemodynamics
Publication Date：2016-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 652-656 )