Effect of trimetazidine combined with metoprolol in preventing fibrillation and asymptomatic atrial fibrillation in patients with pacemaker
Qin Jingmei
Tian Xia
Chen Hui
Liu Ping
Abstract：Objective To explore the effects of trimetazidine combined with metoprolol in preventing atrial fibrillation (AF) and asymptomatic AF in patients with dual chamber pacemaker.Methods Eighty five sick sinus syndrome (SSS) patients with dual chamber pacemaker from January 2010 to January 2015 were randomly divided into control group (41 cases) and observation group (44 cases).Three months after pacemaker implanta tion,control group was orally given metoprolol succinate (47.5 mg/time,once a day) and observation group was orally given metoprolol succinate (47.5 mg/time,once a day) combined with trimetazidine (20 mg/time,3 times/d).The treatment was lasted for 6 months.The patients were followed up before medication (3 months after pacemaker implantation) and 6 months after medication (9 months after pacemaker implantation) to obtain the incidences of AF and asymptomatic AF,the number of mode switch,the AF burden and compared between groups.Results In control group,14 cases (34.1％) had AF including 6 cases (42.9％) of asymptomatic AF before medication,9 cases (22.0％) had AF including 4 cases (44.4％) of asymptomatic AF after medication;the incidence of AF was not significantly changed after medication (x2 =1.51,P ＞ 0.05).The number of mode switch and AF burden were significantly less after medication than those before medication [(69 ± 25) times vs (92 ± 28) times,(8.0 ± 2.7) ％ vs (11.7 ± 4.8) ％] (t =3.92,4.30,P ＜ 0.05).In observation group,the incidence of AF,number of mode switch and AF burden were significantly reduced after medication compared with those before medication [13.6％ (5/44) vs 31.8％ (14/44),(59 ± 19) times vs (101 ± 36) times,(6.5 ±2.2)％ vs (10.5±5.3)％] (x2=5.43,P＜0.05;t=6.84,P＜0.01;t=4.62,P＜0.05).Before medication,the incidence of AF,number of mode switch and AF burden were not significantly different between groups (x2 =0.52,t =1.28,t =1.09,P ＞ 0.05);after medication,the incidence of AF was not significantly different between groups (x2 =1.73,P ＞ 0.05);the number of mode switch and AF burden in observation group were significantly less than those in control group (t =2.09,P ＜ 0.05;t =2.81,P ＜ 0.01).Conclusion AF and asymptomatic AF after dual chamber pacemaker implantation were not uncommon;metoprolol can reduce the AF burden;when combined with trimetazidine,incidence of AF can be further decreased.
Keywords：Atrial fibrillation,asymptomaticCardiac pacingMetoprololTrimetazidine
Publication Date：2016-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 633-637 )