Relative factors of coronary artery disease in middle-aged and elderly patients with rheumatoid arthritis
Ci Weiping
Pan Lili
Wan Jin
Liao Hua
Wang Tian
Abstract：Objective To investigate the relative factors of coronary artery disease (CAD) in middle-aged and elderly patients with rheumatoid arthritis (RA).Methods Clinical data of 136 middle-aged and elderly patients with RA from January 2013 to December 2014,including 76 cases with CAD (observation group) and 60 cases without CAD (control group),were analyzed retrospectively.The gender,age,cause of RA,hypertension,diabetes mellitus,dyslipidemia,smoking and medications were recorded;the body mass index (BMI),systolic blood pressure (SBP) and diastolic blood pressure (DBP),the serum levels of triglyceride,total cholesterol,high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),fasting blood glucose (FBG),high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) were detected.Above indexes were compared between groups,and multivariate Logistic regression analysis was performed to aaalyze the independent predictors of CAD in middle-aged and elderly patients with RA.Results The course of RA was significantly longer,the proportion of hypertension was significantly higher,the usage rates of glucocorticoid hormone and hydroxychloroquine (HCQ) were significantly lower in observation group than those in control group [(15 ± 9) years vs (10±10) years,65.8％ (50/76)vs41.7％ (25/60),23.7％ (18/76)vs46.7％ (28/60),5.3％ (4/76)vs 23.3％ (14/60),P ＜ 0.01].The serum levels of total cholesterol,LDL-C,HDL-C was significantly lower,the level of Hcy was significantly higher in observation group than those in control group [(4.2 ± 1.0) mmol/L vs (4.8±0.9) mmol/L,(2.5 ±0.8) mmol/L vs (2.9±0.8) mmol/L,(1.06±0.30) mmol/L vs (1.20± 0.33) mmol/L,(17 ±8) μmol/L vs (14 ±7) μmol/L] (P ＜0.01 or P ＜0.05).Logistic regression analysis showed that the cause of RA and hypertension were independent risk factors of CAD,the usage of HCQ was a protective factor of CAD in middle-aged and elderly patients with RA [odds ratio:1.054,2.629,0.118;95％ confidence interval:1.009-1.101,1.201-5.755,0.029-0.484].Conclusions Longer cause of RA and hypertension are independent risk factors of CAD,HCQ usage is a protective factor of CAD in middle-aged and elderly patients with RA;actively correcting the immune disorder is of great importance for preventing cardiovascular adverse events in middle-aged and elderly patients with RA.
Keywords：Rheumatoid arthritisCoronary artery diseaseAge
Publication Date：2016-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 629-633 )