Correlation of postprandial hyperglyecmia and carotid atherosclerosis in elderly people
Xi Jianjun
Jia Haiyu
Zhang Yong
Li Changqing
Cao Zhongchao
Abstract：Objective To investigate the correlation between postprandial hyperglycemia and carotid atherosclerosis in the elderly.Methods A total of 183 elderly subjects from May 2012 to October 2013 who had a medical examination were enrolled.According to result of oral glucose tolerance test,the subjects were divided into postprandial hyperglycemia group and normal glucose tolerance group.The intima-media thickness (IMT) and degree of atherosclerotic plaque measured by high-frequency Doppler ultrasound;the levels of total cholesterol (TC),triglycerides (TG),high-density lipoprotein cholesterol,low-density lipoprotein cholesterol (LDL-C),serum urine acid were determined.The correlation between postprandial hyperglycemia and carotid atherosclerosis was analyzed after adjustment of TC,LDL-C and serum urine acid.Results There were 69 cases in postprandial hyperglycemia group and 114 cases in normal glucose tolerance group,the detection rate of postprandial hyperglycemia was 37.7％ (69/183).IMT maximal ralne and detection rate of carotid plaque and the number of carotid plaque in postprandial hyperglycemia group were significantly higher than those in normal glucose tolerance group [(1.39±0.31) mmvs (1.02±0.18) mm,78.3％ (54/69) vs51.8％ (59/114)] (P＜0.05).The levels of TC,TG,LDL-C and serum urine acid,the IMT of common carotid artery and internal carotid artery in postprandial hyperglycemia group were significantly higher/greater than those in normal glucose tolerance group [(4.9 ± 1.0) mmol/L vs (4.5 ±0.8) mmol/L,(2.8 ±0.7) mmol/L vs (1.9 ±0.6) mmol/L,(3.1 ±0.5) mmol/L vs (2.7 ±0.5) mmol/L,(337 ±45) μmol/L vs (291 ±51) μmol/L,(1.27 ±0.28) mm vs (0.96 ±0.16) mm,(1.22±0.29) mmvs (0.92±0.11) mm] (t=4.234,7.019,3.137,4.060,8.536,2.027,P＜0.05).Postprandial hyperglycemia was positively correlated with IMT of common carotid artery,IMT of internal carotid artery,IMT maximal value and plaque numer/per (r =0.454,0.297,0.401,0.276,P ＜ 0.01).Conclusions Postprandial hyperglycemia is closely related with IMT and plaque,which may be an independently risk factor of carotid atherosclerosis and plaque formation in the elderly.
Keywords：Postprandial hyperglycemiaCarotid atherosclerosisElderly
Publication Date：2016-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 540-543 )