Effect of argatroban and low molecular weight heparin calcium in treating acute cerebral infarction:comparison analysis
Wang Xue
Abstract：Objective To compare the effect of argatroban injection and low molecular weight heparin injection in treating acute cerebral infarction.Methods Totally 180 patients with acute cerebral infarction from December 2013 to March 2015 were randomly divided into argatroban group and low molecular weight heparin group (90 cases in each group).Both group received 14 days of conventional therapy.Argatroban group was additionally given argatroban as followed:60 mg diluted into 120 ml 0.9％ sodium chloride injection,continuous infusion with pump for 24 h on the first 2 days;10 mg diluted into 20 ml 0.9％ sodium chloride injection,continuous infusion with pump for 3 h,2 times/d on the next 5 days.Low molecular weight heparin group was additionally given subcutaneous injection of low molecular weight heparin injection (6 000 IU/time,2 times/d) for 10 days.The blood coagulation function [thrombin time (TT),prothrombin time (PT),activated partial clotting enzyme live time (APTT),fibrinogen (FIB) and platelet count (PLT)],the National Institutes of Health Stroke Scale (NIHSS) score,the Barthel index score,clinical efficacy and adverse reactions were compared between groups.Results Before treatment,blood coagulation function were not significantly different between groups (P ＞ 0.05).After 7 d treatment,TT and APTT in low molecular weight heparin were significantly higher than those before treatment [(20.7 ± 1.5) s vs (16.7 ± 1.5) s,(37 ±4) s vs (30 ±4) s],PLT was significantly lower than that before treatment [(164 ± 40) × 109/L vs (190 ± 60) × 109/L] (P ＜ 0.05).The blood coagulation function indices were significantly different between groups (P ＞ 0.05).Before treatment,the NIHSS score and the Barthel index score were not significantly different (P ＞ 0.05);14 d after treatment,the NIHSS score was significantly lower than that before treatment in argatroban group and low molecular weight heparin group [(7 ± 4) scores vs (21 ±4) scores,(12±5) scores vs (21 ±4) scores],and was more lower in argatroban group (P ＜0.05);14 d after treatment,the Barthel index was significantly lower than that before treatment in argatroban group and low molecular weight heparin group [(78 ± 11) scores vs (44 ± 10) scores,(66 ± 10) scores vs (45 ± 10) scores],and was more higher in argatroban group (P ＜0.05).In argatroban group,the effective rate was significantly higher than that in low molecular heparin calcium group [96.7％ (87/90) vs 81.1％ (73/90)];the incidence of adverse reactions was significantly lower than that in low molecular heparin calcium group [1.1％ (1/90) vs 15.6％ (14/90)] (P ＜0.05).Conclusion Argatroban can significantly improve the disturbance of consciousness and neural functions in patients with acute cerebral infarction,with better clinical adaptability and safety compared with low molecular heparin calcium.
Keywords：Acute cerebral infarctionArgatrobanLow molecular weight heparin calciumCurative effect
Publication Date：2016-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 528-532 )