Application value of end-tidal carbon dioxide partial pressure monitoring in patients with acute cardiogenic pulmonary edema receiving early nonivasive positive pressure ventilation
Tang Youyong
Wang Zhengyan
Yang Zhongwei
Li Wei
Shi Ming
Kuang Jun
Abstract：Objective To investigate the application value of end-tidal carbon dioxide partial pressure (PETCO2) monitoring in patients with acute cardiogenic pulmonary edema receiving early nonivasive positive pressure ventilation.Methods Totally 88 patients confirmed as acute cardiogenic pulmonary edema from February 2011 to May 2015 underwent noninvasive positive pressure ventilation.The hemodynamic (heart rate,systolic blood pressure,diastolic blood pressure,mean arterial pressure values,cardiac output,cardiac index and stroke index),blood gas [pH,Arterial partial pressure of oxygen (PaO2),carbon dioxide partial pressure (PaCO2)]and PETCO2 monitoring were proforming before and after ventilation;the prognosis was surveyed.Results The cardiac output,cardiac index and stroke index values were significantly decreased after ventilation compared with those before ventilation [(3.3 ± 1.1) L/min vs (4.1 ± 1.1) L/min,(2.1 ± 0.4) L/(min · m2) vs (2.6 ± 0.6) L/(min · m2),(25 ±7) ml/m2 vs (29 ±4) ml/m2] (P＜0.05);the heart rate,systolic blood pressure,diastolic blood pressure and mean arterial pressure values were not significantly changed after ventilation (P ＞0.05);the pH,PaO2 values were significantly increased,the PaCO2 values were significantly decreased after ventilatory compared with those before ventilation [(7.35 ± 0.45) vs (7.23 ± 0.24),(88 ± 9) mmHg vs (52 ± 8) mmHg,(39 ±8) mmHg vs (47 ±9) mmHg] (P ＜0.05);the PETCO2 values after ventilatory were (34 ± 5) mmHg,significantly higher than that before ventilation [(28 ± 5) mmHg] (P ＜ 0.05).The patients were followed-up to January 2016,12 cases were complicated with cardiovascular adverse events (13.6％);Pearson correlation analysis showed that the prognosis were related to PETCO2,cardiac index,stroke index and PaCO2 before ventilation (r =0.443,0.342,0.294,0.331;P ＜ 0.05).Conclusions Early treatment of noninvasive positive pressure ventilation in acute cardiogenic pulmonary edema can not only improve the heart function and blood gas status,but also has significant effect on PETCO2;PETCO2 monitoring can effectively determine disease situation and predict prognosis.
Keywords：Acute cardiogenic pulmonary edemaEnd-tidal carbon dioxide partial pressureNoninvasive positive pressure ventilationCardiovascular adverse events
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 511-515 )