Effects of statins on carotid intima-media thickness and secretory type Ⅱ A phospholipase A2 in elderly patients with hypertensive

Mao Junhuan; Sun Changqing; Guo Lirong; Li Weihua

doi:10.3760/cma.j.issn.1673-4777.2016.04.008

Abstract：Objective To observe the effects of statins on carotidintima-media thickness (CIMT) and secretory type Ⅱ A phospholipase A2 (sPLA2 Ⅱ A) in elderly patients with hypertension.Methods Totally 101 elderly patients (≥65 years old) from January 2010 to June 2013 were randomly divided into atorvastatin group (52 cases) receiving atorvastatin 20 mg/d for 12 months,and rosuvastatin group (49 cases) receing rosuvastatin 10 mg/d for 12 months.The CIMT was measured by color doppler ultrasound,the level of sPLA2 Ⅱ A in plasma were determined by enzyme linked immunosorbent assay.The of CIMT and sPLA2 Ⅱ A before and after treatment were compared in the two groups.Results The total cholesterol,low-density lipoprotein cholesterol (LDL-C) and triglycerides were significantly reduced compared with those before treatment in atorvastatin group (all P ＜ 0.05),the level of high density lipoprotein cholesterol had no significant change after treatment (P ＞ 0.05).The level of LDL-C was significantly lower in rosuvastatin group than that in atorvastatin group [(1.94 ± 0.51) mmol/L vs (2.11 ±0.25) mmol/L] (P ＜0.05).The maximal CIMT after treatment significantly reduced compared with that before treatment in both atorvastatin group [(1.16 ±0.68) mm vs (1.27 ±0.75) mm] and rosuvastatingroup [(1.18 ±0.59) mm vs (1.31 ±0.62) mm] (P＜0.05).The level of sPLA2 ⅡA was significantly decreased after treatment compared with that before treatment in atorvastatin group [(3.1 ±0.6) μg/L vs (4.4± 1.0) μg/L] and rosuvastatin group [(3.2 ±0.8) μg/L vs (4.4 ± 1.0) μg/L] (P ＜0.05).Conclusion Statins can effectively reduced the level of plasma sPLA2 Ⅱ A and protective function on carotid atherosclerosis in elderly patients with hypertension.