Effect of Shenfu injection on inflammatory factors in patients with acute ST-segment elevation myocardial infarction complicated with cardiogenic shock
Jin Yanyan
Gao Hai
Nie Shaoping
Zhang Xinyong
Yan Yan
Abstract：Objective To investigate the effect of Shenfu injection on inflammatory factors in patients with acute ST-segment elevation myocardial infarction (STEMI) complicated with cardiogenic shock (CS).Methods Totally 60 patients with STEMI complicated with CS who underwent emergency percutaneous coronary intervention and intra-aortic balloon counterpulsation (IABP) from June 2013 to June 2015 were randomly divided into IABP group (30 cases) and IABP + Shenfu group (30 cases).IABP + Shenfu group was given Shenfu injection 100 ml/24 h.The levels of C-reactive protein (CRP) and intedeukin-6 (IL-6) 24,48,72 h after admission were compared between groups.The IABP support duration,hospitalization stay time,incidence of major adverse cerebrovascular events (MACE) in hospital and follow-up period were compared between groups,and the independent risk factors of MACE in hospital were analyzed.Results The CRP level was significantly higher 24,48,72 h after admission than that immediately after admission in IABP + Shenfu group and IABP group [IABP group:(33 ± 5),(35 3),(30 ±3) g/L vs (23 ±5) g/L,IABP + Shenfu group:(31 ±4),(31 ±5),(28 ±5) g/L vs (26± 3) g/L],and in IABF + Shenfu group,it was significantly lower than that in IABP group 48 and 72 h after admission (all P ＜0.05).The IL-6 level in IABP + Shenfu group was significantly higher than that in IABP group immediately after admission [(112 ± 19)ng/L vs (104 ± 10)ng/L] (P ＜0.05),but the difference was not statistically significant 24,48 and 72 h after admission(all P ＞ 0.05).The IABP support duration in IABP + Shenfu group was significantly shorter than that in IABP group [(53 ±5) h vs (87 ± 16) h] (P＜0.05).The hospitalization stay time was not significantly different between IABP + Shenfu group and IABP group [(14 ± 9) d vs (12 ± 8) d] (P ＞0.05).The incidence of MACE in hospital and follow-up was not significantly different between groups.Logistic regression analysis showed that IL-6 was an independent risk factor of in-hospital MACE in patients with STEMI complicated with CS (P =0.001).Conclusion In patients with STEMI complicated with CS who underwent IABP,simultaneous administrated with Shenfu injection can improve the systemic and cardiac muscle cells inflammatory reaction through reduction of IL-6 level,thus to reduce the dependence on IABP and shorten the course of CS.
Keywords：Cardiac shockShenfu injectionIntra-aortic balloon pumpC-reactive proteinInterleukin-6
Publication Date：2016-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 489-493 )