Effect of nicorandil in treating atrial arrhythmia in patients with ischemic cardiomyopathy

Ni Mingke; Zong Wenxia; Lin Li; Zhang Ming; Li Chang

doi:10.3760/cma.j.issn.1673-4777.2016.04.004

Abstract：Objective To investigate the effect of nicorandil in treating atrial arrhythmia in patients with ischemic cardiomyopathy (ICM).Methods Totally 108 ICM patients from January 2012 to December 2014 were randomly divided into control group (52 cases) given conventional treatment and observation group (56 cases) given nicorandil (5 mg/time,3 times/d) based on conventional treatment.The treatment lasted for 8 weeks.Before and after treatment,the echocardiography was used to detect left ventricular ejection fraction (LVEF) and fractional shortening (LVFS),the electrocardiograph and ambulatory electrocardiography were used to detect P wave maximum time limit (Pmax) and P-wave dispersion.The clinical effect,cardiac function,Pmax,P-wave dispersion and serum level of high-sensitivity C-reactive protein (hs-CRP) were detected and compared between groups.Results The total effective rate in observation group was significantly higher than that in control group [83.9％ (47/56) vs 67.3％ (35/52)] (P ＜0.05).The LVEF,LVFS,Pmax,P-wave dispersion and level of hs-CRP were not significantly different between groups (P ＞ 0.05).After treatment,the LVEF and LVFS in observation group were significantly higher than those before treatment and in control group [(51 ± 7)％ vs (39 ± 7) ％,(44 ± 6) ％,(37 ± 9) ％ vs (22 ± 6) ％,(25 ± 6) ％],the Pmax,P-wave dispersion and level of hs-CRP were significantly lower than those before treatment and in control group [(75 ± 18) ms vs (116 ± 13),(89 ± 18) ms,(25±13) msvs (41±18),(38±12) ms,(37 ±7) mg/L vs (49±5),(43 ±5) mg/L] (P＜ 0.05).Conclusion Nicorandil can ameliorate atrial arrhythmia of ischemic cardiomyopathy significantly and can improve the cardiac function and decrease Pmax,P-wave dispersion and hs-CRP level.