Predictive value of bio-distribution of 16α-18 F-17β-estradiol on expression of estrogen receptor in breast cancer
Chen Daobao
Yang Hongjian
Yang Shuye
Abstract：Objective To observe the distribution of 16α-18 F-17β-estradiol (18 F-FES) in normal mice and mice with breast cancer and to analyze its predictive value on the expression of estrogen receptor in breast cancer patients.Methods 18 F-FES was self-prepared.The tumor bearing nude mice of breast cancer MCF-7 cells were established,then the biological distribution and uptake of 18F-FES in normal mice and tumor bearing nude mice were observed and confirmed by micro-positron emission tomography (PET)/CT.Results 18 F-FES was mainly distributed in liver and kidney,and reached peak 60 min after injection in normal mice [liver:30 min:(5.77 ±1.68) ％ID/g,60 min:(8.54±0.45) ％ID/g,120 min:(5.80±0.46) ％ID/g,180 min:(3.61 ± 0.55) ％ID/g;kidney:30 min:(2.28±0.81) ％ID/g,60 min:(2.90±1.22) ％ID/g,120 min:(1.78 ± 1.04) ％ ID/g,180 min:(1.80 ± 1.10) ％ ID/g] and tumor bearing nude mice [liver:30 min:(8.77 ± 2.31) ％ID/g,60 min:(9.29 ±3.47) ％ ID/g,120 min:(13.20 ±4.56) ％ ID/g,180 min:(9.65 ± 5.32) ％ ID/g;kidney:30 min:(3.55 ± 1.31) ％ ID/g,60 min:(6.33 ± 2.65) ％ ID/g,120 min:(4.64 ± 1.87) ％ ID/g,180 min:(2.47 ± 1.53) ％ ID/g].In tumor bearing nude mice The biological distribution and imaging showed that the uptake of 18 F-FES was significantly higher in tumor than that in normal tissues,and reach peak 120 min after injection [30 min:(1.83 ± 0.39) ％ ID/g,60 min:(2.67 ± 1.25) ％ ID/g,120 min:(4.59 ± 1.29) ％ ID/g,180 min:(3.97 ± 1.35) ％ ID/g].Conclusion 18 F-FES shows high intake in the tumor and is expected to be used to study the expression of estrogen receptor in breast cancer patients.
Keywords：Breast cancerEstrogen receptor16α-18 F-17β-estradiolThe tumor bearing nude miceBio-distributionImaging
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 391-395 )