Effect of α-keto acid combined with aescuven forte in treating microalbuminuria

Peng Tao; Zhuang Hongyu; Jiang Yongguang

doi:10.3760/cma.j.issn.1673-4777.2016.03.020

Abstract：Objective To explore the effect of α-keto acid combined with aescuven forte in treating microalbuminuria.Methods One hundred and seventy patients with microalbuminuria from January 2014 were randomly divided into control group (52 cases) without any drug therapy,single treatment group (72 cases) given alpha keto acid (5.04 g,2 times/day),and combined group (46 cases) given alpha keto acid (5.04 g,2 times/day) combined with aescuven forte (0.3 g,2 times/day),all the patients were required low protein diet (LPD);the treatment lasted for 12 weeks.The basic conditions of patients were recorded,including age,sex,body mass index (BMI),smoking or drinking,hypertension or diabetes mellitus.The level of urinary albumin were compared before and after treatment.Results The urinary albumin was influenced by alcohol,smoking,diabetes mellitus,hypertension (all P ＜0.05).Before treatment,the level of urinary albumin was not significantly different among three groups (P ＞ 0.05);12 weeks later,the levels of urinary albumin were all significantly reduced [control group:18.0 (6.7,43.2) mg/24 h vs 43.8 (37.6,48.3) mg/24 h,single treatment group:10.5 (2.5,12.6) mg/24 h vs 38.1 (35.7,44.8) mg/24 h and combined group:3.2 (2.1,6.2) mg/24 h vs 38.7 (35.5,47.5) mg/24 h] (P ＜ 0.05);the level of urinary albumin was significantly lower in single treatment group and combined group than that in control group,and was significantly lower in combined group than that in single treatment group (P ＜ 0.05).Conclusions Microalbuminuria is a sensitive indicator of early renal damage;based on low protein diet,alpha keto acid combined with aescuven forte can effectively control the microalbuminuria timely and reverse the impairment of renal function.