Correlations between metabolic syndrome with resistin, C reaction protein and interleukin-6 in serum
Lu Ke
Wu Dianshui
Tian Meiling
Lu Qingle
Abstract：Objective To explore the correlations between metabolic syndrome with resistin,C reaction protein (CRP) and interleukin-6 (IL-6) in serum.Methods A total of 76 patients with metabolic syndrome (MS) and 36 age matched normal subjects (control group) from September 2013 to March 2014 were enrolled.The patients with MS were divided into obesity MS group [body mass index (BMI) ≥25 kg/m2] and non-obesity MS group (BMI ＜ 25 kg/m2).The height,body weight,waist circumference,hip circumference,BMI,waist-hip ratio,blood pressure,blood lipid,blood glucose were recorded;the homeostasis model assessment insulin resistance index (HOMA-IR) were assessed;the enzyme linked immuosorbent assay was used to determine the resistin level in serum,the immunoturbidimetric assay was used to measure the C reactive protein (CRP) level in serum,the radioimmunity assay was used to meaure the interleukin (IL)-6 level in serum.Results Totally 36 cases were in obesity MS group and 40 were in non-obesity MS group.There were no statistical differences regarding age and sex among the three groups (P ＞0.05).The BMI,waist circumference,hip circumference,waist hip ratio,systolic pressure,diastolic blood pressure,fasting blood glucose,cholesterol,triacyl glycerin,insulin,HOMA-IR,resistin,CRP and IL-6 were significantly higher,the high density lipoprotein cholesterol was significantly lower in obesity MS group and non-obesity MS group than those in control group [(24.4±1.6),(29.5±2.1) kg/m2 vs (22.0±1.5)kg/m2,(84±4),(99±5) cm vs (73±4) cm,(97 ±4),(108 ±5) cm vs (90 ±4) cm,(0.867 ±0.032),(0.913 ±0.034) vs (0.813 ±0.018),(141 ± 14),(148±14) mmHg vs (110 ±10) mmHg,(90 ± 10),(93 ±12) mmHg vs (63 ±6) mmHg,(5.4 ± 1.0),(5.6 ± 1.3) mmol/L vs (4.8 ±0.6) mmol/L,(4.3 ± 1.1),(5.0 ± 1.1) mmol/L vs (3.5 ± 0.8) mmol/L,(2.24 ± 0.78),(3.72 ± 0.90) mmol/L vs (1.01 ± 0.26) mmol/L,(13.4 ± 3.6),(12.9 ± 4.7) MIU/Lvs (7.3 ±2.4) MIU/L,(3.2±1.7),(3.2±1.8) vs (1.5±0.7),(4.5±2.4),(5.1 ± 2.5) μg/L vs (3.2 ±1.9) μg/L,(4.3 ±1.1),(5.8 ± 1.2) mg/L vs (3.0 ±0.5) mg/L,(290 ± 104),(353 ± 120) μg/L vs (184 ± 61) μg/L,(1.20 ± 0.23),(1.07 ± 0.19) mmol/L vs (1.62 ± 0.38) mmol/L] (P ＜ 0.05);the low density lipoprotein cholesterol was not significantly different with that in control group (P ＞ 0.05).The BMI,waist circumference,hip circumference,CRP,IL-6 in obesity MS group were significantly higher than those in non-obesity MS group (P ＜ 0.05);the other indicators had no significant differences between the two groups (P ＞ 0.05).The resistin,CRP and IL-6 were positively correlated with BMI,waist hip ratio,HOMA-IR,respectively (r =0.30,0.25,0.23,r =0.48,0.36,0.32,r =0.32,0.26,0.36,P ＜ 0.05).The resistin was positively correlated with CRP and IL-6 (r =0.22,0.45,P ＜ 0.05),CRP was positively correlated with IL-6 (r =0.34,P ＜ 0.05).Conclusion There are high levels of resistin,CRP and IL-6 in MS patients,and they are correlated with obesity,abodomen obesity and insulin resistance.
Keywords：Metabolic syndromeResistinC reaction proteinInterleukin-6Insulin resistance
Publication Date：2016-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 374-377 )