Influence of modified ultrafiltration on hemodynamic after extracorporeal circulation operation in children with congential heart disease
Liu Yaguang
Jia Qingyan
Han Ding
Pei Xin
He Chen
Ouyang Chuan
Abstract：Objective To explore the influence of modified ultrafiltration on hemodynamic after extracorporeal circulation operation in children with congential heart disease.Methods Totally 48 children with congential heart disease from February to August 2014 undergoing extracorporeal circulation operation were enrolled.The modified ultrafiltration was used during operation with velocity of 10-15 ml/(kg · min);when the hematocrit reached 0.30-0.35 or the residual blood in extracorporeal circulation pipeline was used up,the ultrafiltration was stopped,with duration of 10-15 min.The durations of operation,extracorporeal circulation and ascending aorta blocking,the liquid volume of ultrafiltration filter,the hematocrit were recorded.The hemodynamic parameters,including cardic index,stroke volume index (SVI),systemic vascular resistance index (SVRI),maximum pressure rise rate (dp/dt),heart rate,systolic pressure,diastolic blood pressure,DicP were recorded when extracorporeal circulation was stopped (T0),1 min (T1),2 min (T2),5 min (T3),10 min (T4) after modified ultrafiltration.Results The durations of operation,extracorporeal circulation and ascending aorta blocking were respectively 95-165 min,20-55 min and 12-34 min;the liquid volume of ultrafiltration filter was 150-300 ml;the hematocrit in extracorporeal circulation was 0.20-0.25,and was 0.30-0.35 after modified ultrafiltration.At T0-T4,no significant changes of heart rate were observed;the cardic index,SVI,dp/dt,systolic blood pressure,diastolic blood pressure,DicP at T1,T2,T3,T4 were significantly higher than those at T0[(3.1±0.7),(3.3±0.7),(3.4±0.9),(3.4±0.9)L/m2 vs (2.4±0.5)L/m2;(22±6),(24±6),(25±8),(25±8)ml/m2 vs (18 ±6)ml/m2;(1.15±0.23),(1.20±0.26),(1.23±0.28),(1.21 ± 0.27) mmHg/msvs (1.03±0.29) mmHg/ms;(103 ±12),(108±13),(110±15),(109±13) mmHg vs (87±14) mmHg;(54±10),(56±10),(57±10),(58±11) mmHg vs (44±9) mmHg;(66±13),(68± 13),(71 ± 16),(71 ± 15) mmHg vs (53 ± 11) mmHg],the SVRI was significantly lower than that at T0 [(1 728 ±373),(1 677 ±354),(1 658 ±317),(1 683 ±381)dyne · s · m2/crn5 vs (1 805 ±317)dyne · s · m2/cm5] (P ＜0.05);the cardic index,SVI,dp/dt,diastolic blood pressure,systolic blood pressure,DicP at T2,T3,T4 were significantly higher than those at T1 (all P ＜ O.05).Conclusion Modified ultrafiltration can significantly improve the hemodynamics after extracorporeal circulation operation in children with congential heart disease.
Keywords：Congenital heart diseaseCardiopulmonary bypassModified ultrafiltrationHemodynamics
Publication Date：2016-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 347-349 )