Effect of statin loading before percutaneous coronary intervention on reducing incidences of cardiovascular events: a Meta-analysis

Shi Shaohu; Liu Yun; Chen Chuanmin

doi:10.3760/cma.j.issn.1673-4777.2016.03.009

Abstract：Objective To assess the effect of statin loading before percutaneous coronary intervention (PCI) on reducing the incidences of cardiovascular events through Meta-analysis.Methods The randomized controlled trials about statin loading/placebo before PCI were retrieved in Medline,Pubmed and Excerpta medica database (Embase).Meta analysis was used to assess the influences of statin loading before PCI on incidences of periprocedural myocardial infarction (pMI) and endpoint events including death,spontaneous myocardial infarction and target vessel revascularization.Results Totally 14 literatnres including 3 146 patients were enrolled.Among 3 146 cases,1 591 patients were given loading dose of statin before PCI (observation group) and 1 555 patients were not given statin loading before PCI (control group).The incidences of pMI and combined endpoint events in observation group were significantly lower than those in control group (OR:0.44,95％ CI:O.35-0.56,P ＜ 0.000 01;OR:0.59,95％ CI:0.38-0.92,P =0.02).The incidence of pMI in observation group was significantly lower than that in control group in both patients with stable angina pectoris (OR:0.33,95％ CI:0.22-0.50,P ＜0.000 01)and patients with non-ST elevation acute coronary syndrome (NSTE-ACS) (OR:0.32,95％ CI:0.19-0.53,P ＜0.000 1);in patients with stable angina pectoris,the incidence of combined endpoint events was not significantly different between groups (OR:0.92,95％ CI:0.53-1.61,P=0.78),while in patients with NSTE-ACS,the incidence of combined endpoint events in observation group was significantly lower than that in control group (OR:0.18,95 ％ CI:0.07-0.47;P =0.000 5).Conclusions Statin loading before PCI can significantly reduce the incidences of pMI and short-term cardiovascular events.