Protective mechanism of Chaiqi decoction in vascular disease in metabolic syndrome model rats
Chen Liru
Nie Wei
Malina Axinbai
Liu Yuan
Zhang Jiayan
Peng Long
Zhang Liping
Abstract：Objective To observe the effects of Chaiqi decoction on serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) level in metabolic syndrome (MS) model rats.Methods Three two rats were randomly divided into normal group,model group,Chaiqi decoction group and rosiglitazone group.The MS model was established by feeding high fat,high sugar and high salt diet for 8 weeks.After 8 weeks,the levels of serum ICAM-1 (sICAM-1) and serum VCAM-1 (sVCAM-1) were measured by enzyme-linked immunosorbnent assay.The pathological characteristics of abdominal aortic vessel were observed and the expressions VCAM-1 and ICAM-1 in aorta tissue were inspected by immunohistochemistry.Results The fasting blood glucose,fasting insulin (FINS),insulin resistance index (IRI),triglyceride,total cholesterol,low density lipoprotein-cholesterol (LDL-C) were significantly increased in model group compared with normal group [(6.7±0.7) mmol/L vs (5.7 ±0.4) mmol/L,(15.8±1.1) μIU/ml vs (13.5 ±1.5) μIU/ml,(4.7± 0.7) vs (3.4 ±0.3),(0.89 ±0.43) mmol/L vs (0.41 ±0.08) mmol/L,(2.73 ±0.65) mmol/L vs (1.39 ± 0.17) mmol/L,(0.93 ±0.22) mmol/L vs (0.60 ±0.03) mmol/L] (P ＜0.05);.the FINS,IRI,triglyceridc and LDL-C in Chaiqi decoction group and rosiglitazone group were significantly reduced [(14.2 ±0.6),(14.2 ±1.9)μIU/ml,(3.4±0.7),(3.9±0.8),(0.44±0.09),(0.40±0.12) mmol/L,(0.75±0.14),(0.70±0.20) mmol/L] (P ＜ 0.05),while they were not significantly different between Chaiqi decoction group and rosiglitazone group (P ＞0.05).The levels of sVCAM-1 and sICAM-1 in Chaiqi decoction group and rosiglitazone group were significantly lower than those in model group [(34.4 ± 0.8),(33.8 ± 1.4) ng/L vs (36.6 ±1.2) ng/L;(306 ± 14),(338 ± 11) μg/L vs (357 ± 15) μg/L] (P ＜ 0.05).The pathological result showed that the lesion degree in Chaiqi decoction group and rosiglitazone group was significantly alleviated compared with that in model group.Immunohistochemistry result showed that the expression levels of ICAM-1 and VCAM-1 in Chaiqi decoction group and rosiglitazone group were significantly lower than those in model group [ICAM-1:(3.0 ±2.0),(3.0 ±1.4) vs (6.8 ±2.2);VCAM-1:(3.2 ± 1.1),(3.6 ± 1.7) vs (6.8 ±2.2),P＜0.05],while no significant difference was found between Chaiqi decoction group and rosiglitazone group (P ＞ 0.05).Conclusion Chaiqi decoction has the similar effect with rosiglitazone in treating MS;both them can regulate the blood lipid level,reduce the levels of sICAM-1 and sVCAM-1,inhibit the expressions of VCAM-1 and ICAM-1 in aorta tissue,thus to prevent the atherosclerosis effectively.
Keywords：Metabolic syndromeChaiqi decoctionIntercellular adhesion molecule-1Vascular cell adhesion molecule-1
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 216-221 )