Effect of different doses of irbesartan on pre-hypertension in young people
Hong Zewen
Lai Guoyong
Lu Shiwen
Wang Wu
Lai Min
Abstract：Objective To explore the effect of different dosages of irbesartan on pre-hypertension in young people.Methods Totally 362 young people with pre-hypertension from January 2008 to December 2012 were randomly divided into control group (86 cases),irbesartan low dose (25 mg,90 cases),middle dose (75 mg,92 cases) and high dose group (150 mg,cases).The average blood pressure of 6,12 and 18 months after treatment was calculated;the incidences of hypertension,adverse drug reactions and cerebrovascular diseases after treatment were compared between the two groups.Results After treatment,the average systolic blood pressure (SBP) and diastolic blood pressure (DBP) had no significant changes compared with those before treatment in irbesartan low dose group and control group (P ＞ 0.05),while average SBP,DBP in irbesartan middle,high dose group were significantly lower than before treatment,control group and low dose group [(128 ± 5) mmHg vs (136 ±5),(139 ±5),(137 ±4) mmHg,(82 ±6) mmHg vs (87 ±6),(87 ±6),(86 ±5) mmHg] and high dose group [(125 ±6) mmHg vs (136 ±7) mmHg,(78 ±7) mmHg vs (88 ±6) mmHg] (P ＜0.05).The incidences of hypertension in control group,irbesartan low dose,middle dose,high dose group were 22.1％ (19/86),11.1％ (10/90),9.8％ (9/92),8.5％ (8/94) (x2 =9.24,P＜0.05);in irbesartan high dose group the incidence was significantly higher than that in control group (P ＜ 0.05).There were no statistical differences regarding incidence of in cardiovascular disease among different groups (P ＞ O.05).No moderate or serious adverse reactions were observed in all the groups.Conclusion Large doses of irbesartan is safe and effective in young population with pre-hypertension.
Keywords：Pre-hypertensionIrbesartanDosageYouth
Publication Date：2016-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 189-191 )