Effect of amlodipine combined with hydrochlorothiazide on steady reduction of blood pressure and protection of target organ in elderly patients with hypertension
Gao Fei
Li Jun
Dong Shaohong
Mai Aihuan
Zhang Zhuohui
Abstract：Objective To explore the effect of amlodipine combined with hydrochlorothiazide on steady reduction of blood pressure and protection of target organ in elderly patients with hypertension.Methods Totally 134 elderly patients with hypertension from January 2013 to October 2014 were randomly divided into observation group (67 cases) and control group (67 cases).Control group was given hydrochlorothiazide (12.5 mg daily) and observation group was given amlodipine (5 mg daily) combined with hydrochlorothiazide (12.5 mg daily) after washout period.The blood pressure,parameters of ultrasound,renal function indicators before and after treatment were compared between the two groups.Results The 24 h average blood pressure,24 h blood pressure variety ratio and 24 h blood pressure load were significantly lower,the 24 h trough/peak blood pressure ratio and nighttime blood pressure drop rate were significantly higher in observation group than those in control group [systolic blood pressure/diastolic blood pressure:(125 ± 13) / (82 ± 8) mmHg vs (138 ± 14) / (91 ± 9) mmHg,(10.1 ±1.2)％/(8.3±1.1)％ vs (15.3±1.4)％/(10.6±1.3)％,(10.3 ±1.3)/(10.5±1.1) mmHgvs (15.6±1.7)/(14.8±1.5) mmHg,(76.2 ±7.7)％/(74.8 ±7.5)％ vs (67.2 ±6.8)％/(71.4 ±7.2)％,(12.1±1.4)％/(11.6±1.2)％ vs (10.0±1.4)％/(9.8±1.3)％] (P＜0.05).After treatment,the left ventricular mass (LVMI),intima-media thickness (IMT),plaque Crouse score were significantly lower than before treatment,the left ventricular ejection fraction (LVEF) was higher than before treatment [observation group:(107±8)g/m2 vs (119 ±9)g/m2,(0.65 ±0.03)mm vs (0.82±0.07)mm,(3.2±0.4)scores vs (4.9 ± 0.5) scores,(66 ± 9) ％ vs (54 ± 8) ％;control group:(113 ± 9) g/m2 vs (118 ± 9) g/m2,(0.77 ± 0.09)mm vs (0.83 ± 0.05) mm,(3.3 ± 0.5) scores vs (4.7 ± 0.4) scores,(59 ± 7) ％ vs (53 ± 8) ％];the LVMI,IMT,Crouse score were significantly lower,the LVEF was significantly higber in observation group than those in control group (P ＜ 0.05).In two groups,the microalbuminuria (MAU),MAU/creatinine ratio after treatment were significantly lower than before treatment;the endogenous creatinine clearance rate (Ccr) was significantly higher than before treatment [observation group:(38 ± 12) mg/L vs (55 ± 14) mg/L,(1.34 ± 0.26) mg/μmol vs (3.99 ± 0.24) mg/μmol,(86 ± 16) ml/min vs (69 ± 15) ml/min;control group:(48 ± 13)mg/L vs (56 ± 14)mg/L,(2.15 ±0.39)mg/μ mol vs (4.01 ±0.26)mg/μmol,(75 ± 14) ml/min vs (68 ± 15) ml/min],and the MAU,MAU/creatinine in observation group were significantly lower,Ccr was significantly higher than control group (P ＜ 0.05).Conclusion Amlodipine combination with hydrochlorothiazide can steadly reduce blood pressure and improve the subclinical lesions of target organs.
Keywords：HypertensionAmlodipineHydrochlorothiazideAmbulatory blood pressure monitorTarget organ
Publication Date：2016-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 185-188 )