Correlations between synthesis and absorption of cholesterol in population with high risks of coronary atherosclerosis heart disease and their reactivity to statin drugs
Ren Jie
Bai Na
Zhang Liangqing
Zhu Lijun
Chen Xiaoping
Wang Qihui
Li Bao
Abstract：Objective To investigate the correlations between synthesis and absorption of cholesterol in population with high risks of coronary atherosclerosis heart disease and the reactivity to statin drugs of the patients.Methods Totally 159 subjects with high risks of coronary atherosclerosis heart disease from May 2009 to April 2010 were enrolled and given atorvastatin (20 mg,1 time/d) for 4 weeks.The levels of total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),triacylglycerol and squalene,sitoesterol,squalene/TC and sitoesterol/TC were determined before and after treatment.According to the ratio of squalene/TC,the subjects were divided into very low synthesis group (≤ 17,33 cases),low synthesis group (＞ 17-66,40 cases),high synthesis group (＞66-131,40 cases) and very high synthesis group (＞ 131,40 cases);according to ratio of sitoesterol/TC,the subjects were divided into very low absorption group (≤ 138,33 cases),low absorption group (＞ 138-164,40 cases),high absorption group (＞ 164-202,40 cases) and very high absorption group (＞ 202,40 cases).The general data of the subjects were analyzed,and the reactivity to statin drugs were compared among groups.Results The age,proportions of smoker and drinker,levels of HDL-C and squalene were significantly differently between males and females [(54 ± 10) years vs (58 ± 8) years,38.0％ (27/71) vs 3.4％ (3/88),19.7％ (14/71) vs 0.0％ (0/88),(1.4 ±0.3) mmol/L vs (1.5± 0.3) mmol/L,(0.42 ± 0.05) mg/ml vs (0.58 ± 0.07) mg/ml] (P ＜ 0.05),the rest of the index had no statistical significance difference (P ＞ 0.05).the subjects of very low synthesis,low synthesis,high synthesis and very high synthesis accounted for 12.8％ (5/39),15.8％ (6/39),30.8％ (12/39),41.0 (16/39);in very low absorption group and 35.0％ (14/40),37.5％ (15/40),30.0％ (8/40),7.5 (3/40) in very high absorption group;there were significant difference between the two groups (P ＜ 0.01),with increase of synthesis,proportion of high absorption was decreased.Similarly,with increase of absorption,propotion of high synthesis was decreased (P ＜0.01).After treatment with statin,the synthesis of 38.5％ (15/39) subjects in very low synthesis group and of 82.5％ (33/40) subjects in very high synthesis group was reduced,with significant difference between the two groups (P ＜ 0.01);with increased of synthesis,the propotion of subjects with reduced synthetic levels was gradually increased (P ＜0.01).After treatment with statin,the synthesis of 69.2％ (27/39) subjects in very low absorption group and of 62.5％ (25/40) subjects in very high absorption group was reduced,with significant difference between the two groups (P =0.035);with increased of absorption,the propotion of subjects with reduced synthetic levels was gradually decreased (P =0.033).Conclusions In population with high-risk of coronary heart disease,there is a negative feedback regulation mechanism between cholesterol synthesis and absorption;the higher cholesterol synthesis,the better reactivity to statin,but it shows the opposite tendency for cholesterol absorption.
Keywords：Coronary artery diseaseCholesterol synthesisCholesterol absorptionAtorvastatinReactivity
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 150-154 )