Effect of low dose flupentixol and melitracen tablets combined with rabeprazole, mosapride in treating non-erosive gastroesophageal reflux disease complicated with alexithymia
Li Di
Li Zengnan
Xue Ganggang
Zhang Rendan
Xu Chunhua
Shi Wei
Abstract：Objective To observe the effect of low dose flupentixol and melitracen tablets combined with rabeprazole, mosapride in treating non-erosive gastroesophageal reflux disease complicated with alexithymia.Methods Totally 60 patients with non-erosive gastroesophageal reflux disease complicated with alexithymia from January 2014 to January 2015 were randomly divided into observation group and control group (30 cases in each groups).Control group was given oral administration of rabeprazole (20 mg/time, once daily) and mosapride (5 mg/time, 3 times/d);observation group was additionally given oral administration of flupentixol and melitracen tablets (1 tablet, once daily before breakfast).The treatment was lasted for 8 weeks.The reflux disease diagnostic questionnaire (RDQ scale) score, Zung self rating anxiety scale (SAS) score and Zung depression self rating scale (SDS) score on the 1 st day and 8 weeks after treatment were assessed;the effective rate and incidence of adverse reaction were compared between groups.Results The RDQ scale score, SAS scores and SDS score after 8 weeks of treatment were significantly lower than those on the first day after treatment in observation group [(6.1 ±1.5) scores vs (12.2 ± 1.7) scores, (36 ± 10) scores vs (54 ± 11) scores, (36 ± 10) scores vs (50 ±12) scores] and control group [(9.1 ± 1.6) scores vs (11.3 ± 1.5) scores, (53 ± 11) scores vs (55 ±11) scores, (46 ± 11) scores vs (48 ± 12) scores], all the scores were significantly lower in observation group than those in control group 8 weeks after treatment (P ＜ 0.05).The effective rate in observation group was significantly higher than that in control group [93.3％ (28/30) vs 60.0％ (18/30)] (P ＜ 0.05).Four cases in observation group had dry mouth and bitter mouth, 6 cases in control group had with drowsiness.Conclusion Low dose flupentixol and melitracen tablets combined with rabeprazole, mosapride can enhance the effect in treating ulceratie gastroesophageal reflux disease complicated with alexithymia.
Keywords：Non-erosive gastroesophageal reflux diseaseFlupentixol and melitracen tabletsRabeprazoleMosaprideAlexithymia
Publication Date：2016-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 62-66 )