Effect of flupentixol and melitracen tablets combined with gastric motor drug in treating non-erosive gastroesophageal reflux disease complicated with depression
Zhong Mei
Zhang Bing
Li Xiumei
Abstract：Objective To investigate the effect of flupentixol and melitracen tablets (deanxit) combined with gastric motor drug in treating non-erosive gastroesophageal reflux disease (NERD) complicated with depression.Methods Toally 97 NERD patients complicated with depression from January 2009 to December 2014 were enrolled and randomly assigned into itopride group (32 cases) receiving itopride (50 mg/time, 3 times/d), deanxit group (33 cases) receiving deanxit (1 tablet/time, 2 times/d) and combination group (32 cases) receiving deanxit combined with itopride.Before and after 12 weeks of treatment, the reflux disease questionnaire (RDQ) score was used to assess the efficacy, and the Hamilton depression (HAMD) scale was used to assess the depression degree, the 36-item short form health survey (SF-36) was used to assess the life quality.Results After treatment, The RDQ symptom scores (including reflux, heartburn, acid reflux, noncardiac chest pain) and RDQ total scores were significantly decreased compared with those before treatment in itopride group [(0.98 ±0.61) scores vs (6.09 ± 1.63) scores, (0.98 ±0.62) scores vs (6.01 ± 1.74) scores, (0.81 ±0.34) scores vs (6.21 ±1.61) scores, (1.14±0.71) scores vs (5.92 ±1.41) scores, (3.91 ±0.64) scores vs (24.53 ±2.01) scores], deanxit group [(1.25 ±0.91) scores vs (5.87 ± 1.51) scores, (1.31 ±0.74) scores vs (6.02±1.85) scores, (1.01±0.64) scores vs (5.99 ± 1.71) scores, (1.18±0.76) scores vs (6.15 ±1.45) scores, (4.72 ± 0.85) scores vs (24.02 ± 1.93) scores] and combination group [(0.43 ± 0.35) scores vs (6.14±1.49) scores, (0.32±0.28) scores vs (6.11 ±1.98) scores, (0.29±0.24) scores vs (6.24±1.58) scores, (0.65 ± 0.53) scores vs (6.38 ± 1.43) scores, (1.64 ± 0.32) scores vs (24.98 ±1.95) scores] (P ＜0.05);the RDQ total score was significantly higher in deanxit group compared with that in itopride group, the RDQ symptom scores and total score were significantly lower in combination group compared with those in itopride group and deanxit group (P ＜ 0.05).The effective rates in itopride group and deanxit group had no significantly difference, which were both significantly lower than that in combination group [75.0％(24/32), 63.6％ (21/33) vs 90.6％ (29/32)] (P＜0.05).Compared with that before treatment, the HAMD score was significantly decreased after treatment in deanxit group [(12.4 ±6.2) scores vs (22.1 ± 1.9) scores]and combination group [(9.7 ± 6.8) scores vs (21.9 ± 1.8) scores] , significantly lower than that in itopride group after treatment [(20.3 ± 6.5) scores] (P ＜ 0.05).In SF-36 score, the item scores were improved except for physical limitation in all groups;the vitality, social function, emotional function and mental health scores were significantly higher in deanxit group and combination group compared with those in itopride group [(92 ± 7), (94 ± 7) scores vs (71 ± 6) scores, (90 ± 7) , (97 ± 5) scores vs (77 ± 6) scores, (80 ± 7) , (87 ± 6) scores vs (70 ± 6) scores, (80 ± 6), (83 ± 7) scores vs (72 ± 6) scores], the social function and emotional function scores in combination group were significaltly higher than those in deanxit group, in addition, the body pain and general health scores were also significantly higher in combination group compared with those in itopride group [(84±6) scores vs (78±6) scores, (78±6) scores vs (71 ±6) scores] (P＜0.05).Conclusion Deanxit combined with itopride treatment can significantly improve the quality of life and enhance the curative effect in NERD patients complicated with depression.
Keywords：Non-erosive gastroesophageal reflux diseaseFlupentixol and melitracen tabletsItoprideDepression
Publication Date：2016-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 58-62 )