Correlation between lipoprotein associated phospholipase A2 and cervical vascular disease in patients with type 2 diabetes mellitus
Yao Fei
Yu Qiurong
Gong Ye
Kong Yinghong
Abstract：Objective To explore the correlation between the level of lipoprotein associated phospholipase A2(Lp-PLA2) and cervical vascular disease in patients with type 2 diabetes mellitus (T2DM).Methods Totally 76 patients with T2DM from July 2014 to March 2015 underwent carotid artery color Doppler ultrasound to measure the intima-media thickness (IMT) and were divided into simple T2DM group and T2DM with cervical vascular complication group according to the results of ultrasound.Meanwhile, 40 cases of healthy people who received physical examination were selected as control group.The level of fasting blood-glucose (FBG) , hemoglobin A1c (HbA1 c), triacylglycerol, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterin (LDL-C), apolipoprotein (Apo) A1, ApoB, homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP) and Lp-PLA2 were detected and compared among groups.Results There were 36 cases in simple T2DM group and 40 cases in T2DM with cervical vascular complication group.There were no statistical differences regarding gender, age, triacylglycerol, total cholesterol, LDL-C, HDL-C, ApoA1 , ApoB were found among groups (P ＞ 0.05).The levels of FBG, HbA1 c, Hcy, Lp-PLA2 in simple T2DM group and T2DM with cervical vascular complication group were significantly higher than those in control group [(8.5 ± 2.9), (8.1 ± 3.1) mmol/L vs (5.2±0.4) mmol/L;(8.4±2.7), (9.3±2.9)％ vs (5.3±0.5)％;(9±4), (14±5) μmol/L vs (6± 3) μmol/L;(131 ± 32), (283 ± 66) μg/L vs (69 ± 16) μg/L];the duration of diabetes was significantly longer, the levels of Hcy, hs-CRP, Lp-PLA2 were significantly higher in T2DM with cervical vascular complication group compared with those in simple T2DM group [(9 ± 6) years vs (4 ± 3) years, (14 ± 5)μmol/L vs (9 ±4) μmol/L, (5.2 ± 2.5) mg/L vs (3.5 ± 2.1) mg/L, (283 ± 66) μg/L vs (69 ± 16) μg/L];the IMT and ApoB/ApoA1 T2DM with cervical vascular complication group were significantly higher than those in control group and simple T2DM group [(1.08 ±0.16) mmvs (0.69 ±0.06), (0.73 ±0.10) mm;(0.78 ±0.22) vs (0.54 ± 0.18), (0.60 ± 0.24)] (P ＜ 0.05).The level of Lp-PLA2 was positively correlated with IMT, Hcy, hs-CRP and ApoB/ApoA1 ratio (r =0.402, 0.335, 0.226, 0.214, P ＜ 0.05) , and it was negatively correlated with ApoA1 (r =-0.205, P ＜ 0.05).Multiple stepwise regression analysis showed that IMT and Hcy were risk factors of Lp-PLA2 [Y =2.312 + 0.724X1 + 0.163X2 (X1 =IMT, X2 =Hcy)].Logistic regression analysis showed that IMT and plasma Lp-PLA2 were the risk factors of neck vascular lesions in T2DM (P =0.003, 0.011).Conclusion Lp-PLA2 is one of the independent risk factors of cervical vascular complication in T2DM patients.
Keywords：Diabetes mellitus,type 2AngiopathiesLipoprotein associated phospholipase A2Carotid artery intima-media thickness
Publication Date：2016-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 50-54 )