Anesthesia efficacy of dexmedetomidine combined with propofol and remifentanil in patients undergoing cerebral aneurysm clamping surgery
Chen Dongmei
Yan Jianping
Abstract：Objective To evaluate the anesthesia efficacy of dexmedetomidine combined with propofol and remifentanil in patients undergoing cerebral aneurysm clamping surgery.Methods Sixty patients undergoing cerebral aneurysm clamping surgery from February 2014 to January 2015 were randomly divided into dexmedetomidine group (30 cases) and control group (30 groups).Dexmedetomidine was injected before anesthesia induction with a loading dose of 1.0 μg/kg (10 min) followed by 0.4 μg/(kg · h) till extubation in dexmedetomidine group;the same volume of 0.9％ sodium chloride was injected in control group.Anesthesia induction was performed by target controlled infusion of propofol, remifentanil and intravenous infusion of rocuronium in both groups.The heart rate and mean arterial pressure (MAP) before and after intubation (T1 and T2), before and after extubation (T3 and T4) were monitored;doses of remifentanil, rocuronium and propofol, the time of extubation and anesthesia recovery, the complications during operation and anesthesia recovery period were recorded.Results The MAP and heart rate were significantly lower/slower in dexmedetomidine group than those in control group at T1 [(92 ± 10) mmHg vs (110 ± 9) mmHg, (72 ± 11) times/min vs (77 ± 11) times/min], T2 [(94 ± 1 1) mmHg vs (127 ± 12) mmHg, (71 ±10) times/min vs (93 ± 12) times/min], T3 [(93-9) mmHg vs (109 ± 11) mmHg, (74 ± 10) times/min vs (79±13) times/min], and T4 [(95 ± 10) mmHg vs (125 ± 12) mmHg, (76 ± 11) times/min vs (113 ± 13) times/min] (P ＜ 0.05).The amount of propofol consumed was significantly less in dexmedetomidine group compared with that in control group [(1 058 ±471) mg vs(1 410 ±420) mg] and the time of anesthesia recovery in dexmedetomidine group was significantly prolonged compared with that in control group [(36 ± 6) min vs (13 ±5) min] (P ＜ 0.05).The usages of remifentanil and rocuronium had no significant differences between groups (P ＞0.05).The incidences of hypertension and tachycardia during operation, the incidences of restlessness, vomitting, hypertension, tachycardia during anesthesia recovery period in dexmedetomidine group were significantly lower than those control group [3.3％ (1/30) vs 26.7％ (8/30) ,0.0％ (0/30) vs 13.3％ (4/30) , 10.0％ (3/30) vs 66.7％ (20/30) ,0.0％ (0/30) vs 10.0％ (3/30), 13.3％ (4/30) vs 83.3％ (25/30) ,6.7％ (2/30) vs 90.0％ (27/30)] (P ＜ 0.05).Conclusion Dexmedetomidine combined with propofol and remifentanil can effectively reduce the cardiovascular response during intubation and extubation in patients undergoing cerebral aneurysm clamping surgery, which provides satisfactory efficacy and maintains good hemodynamic stability.
Keywords：Intracranial aneurysmDexmedetomidinePropofolAnesthesiaintravenous
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 38-41 )