Correlations between gene mutation of epidermal growth factor receptor and lipid metabolism in lung cancer
Wang Chun'e
Chen Zhibin
Chen Keqiang
Zhang Hongying
Abstract：Objective To investigate the correlations between gene mutation of epidermal growth factor receptor (EGFR) and lipid metabolism in lung cancer, and to explore the related factors that may predict EGFR gene mutations.Methods A total of 107 patients with lung cancer from June 2011 to February 2015 were enrolled.The EGFR protein levels were tested by EliVision Plus immunohistochemistry, then the gene mutation was measured by ARMS-Real-Time PCR.According to the mutation result, the patients were divided into mutation group and non-mutation group.The general data and the levels of total cholesterol, triacylglycerol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B were compared between the two groups.The correlations between above indices with EGFR mutation were analyzed.Results There were 65 cases in mutation group and 42 cases in non-mutation group.The levels of triglyceride and body mass index in mutation group were significantly higher than those in non-mutation group [(1.6±1.0) mmol/Lvs (1.0±0.5) mmol/L, (22.7 ±2.6) kg/m2 vs (20.8 ±3.7) kg/m2, P＜0.05].While the levels of total cholesterol, HDL-C, LDL-C, apolipoprotein A1, apolipoprotein B were no statistically different between the two groups (P ＞ 0.05).The mutation rate of EGFR gene was significantly higher in female patients than that in male patients [(65.2％ (15/23) vs 32.1％ (27/84),x2 =8.722, P＜0.05], was significantly higher in non-smokers than that in smokers [52.8％ (28/53) vs 25.9％ (14/54), x2 =8.120, P ＜ 0.05] , was significantly higher in adenocarcinoma than that in squamous cell carcinoma [53.7％ (36/67) vs 10.3％ (3/29), x2=15.795, P ＜ 0.05].Logistic regression analysis result showed that the triglycerides and histological type were predictors of EGFR mutations (P ＜ 0.05).Conclusions In lung cancer patients, EGFR mutation may be involved in abnormal lipid metabolism.Increased triglyceride and histological type might be one of predictors of EGFR mutations.
Keywords：Lung cancerEpidermal growth factor receptorGene mutationsLipid metabolism
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 30-34 )