Correlation between severity of coronary lesion and renal function in patients with acute coronary syndrome
Wang Yang
Mi Shuhua
Su Gong
Yang Hongxia
Abstract：Objective To investigate the correlation between severity of coronary lesion and renal function in patients with acute coronary syndrome (ACS).Methods A total of 209 patients with ACS who underwent coronary angiography were enrolled and divided into normal renal function group [estimated glomerular filtration rate (eGFR)≥90 ml/(min · 1.73 m2), 65 cases], mild renal dysfunction group [eGFR 60-89 ml/(min · 1.73 m2),115 cases] and moderate/severe renal dysfunction group [eGFR ＜ 60 ml/(min · 1.73 m2), 29 cases].The severity of coronary lesion was assessed by Gensini score.The correlation between eGFR and the severity of coronary lesion was analyzed.The patients were divided into single/double lesion group and three/left main lesion group.The clinical characteristics of the two groups were compared.Results The proportion of severe coronary lesions and Gensini score in mild renal dysfunction group and moderate/severe renal dysfunction group were significantly higher than those in normal renal function group [78.3％ (90/115), 75.9％ (22/29) vs 53.8％ (35/65);(75 ± 42), (78 ± 37) scores vs (48 ± 29) scores] (all P ＜ 0.05).The proportions of diabetes and hypertension in group B were significantly higher than those in group A [61.2％ (90/147) vs 23.7％ (14/59), 78.2％ (115/147) vs 55.9％ (33/59)];the the level of hemoglobin A1c (HbA1c) and Gensini score in group B were significantly higher than that in group A [(7.5 ± 1.6) ％ vs (6.3 ± 0.9) ％;(77 ± 39) scores vs (43 ± 30) scores] (all P ＜ 0.05).The eGFR in group B was significantly lower than that in group A [(77 ± 17) ml/(min · 1.73 m2) vs (85 ±21) ml/(min · 1.73 m2)] (P ＜0.05).The Gensini score was positively correlated with age (r =0.278, P ＜ 0.001), body mass index (r =0.170, P =0.015) and HbA1c (r =0.385,P ＜ 0.001), was negatively correlated with left ventricular ejection fraction (r =-0.227, P =0.001) and eGFR (r =-0.362, P ＜ 0.001).Logistic regression analysis indicated that renal dysfunction (odd ratio =3.093, 95％ confidence interval: 1.599-5.984, P =0.001) and HbA1 c (odd ratio =1.930, 95％ confidence interval: 1.300-2.866, P =0.001) were independent risk factors of severe coronary lesions.Conclusions The severity of coronary lesion is correlated with eGFR.Renal dysfunction and HbA1c are independent risk factors of severe coronary artery disease.
Keywords：Acute coronary syndromeRenal functionCoronary lesionsRisk factors
Publication Date：2016-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 16-21 )