Effect of Shenqi fuzheng injection combined with human recombinant endostatin in treating advanced gastric cancer and its influence on serum matrix metalloproteinases
Geng Hua'e
Li Yanjie
Li Guoqing
Abstract：Objective To investigate the effect of Shenqi fuzheng injection combined with human recombinant endostatin in treating advanced gastric cancer and its influence on serum matrix netalloproteinase (MMP)-2, MMP-7, MMP-11.Methods Totally 136 patients with advanced gastric cancer from January 2013 to December 2014 were retrospectively analyzed.According to therapeutic schemes, the patients were divided into control group (64 cases) and observation group (72 cases).Both groups received FOLFOX regimen and human recombinant endostatin (7.5 mg/m2 , intravenous infusion, 1 time/d for 2 weeks, followed by 1 week break, 1 course consisted 3 weeks);observation group additionally received Shenqi fuzheng injection (250 ml,intravenous infusion, 1 time/d).The treatment was lasted for 2 courses.The short-term effective rate, the levels of serum MMP-2, MMP-7, MMP-11, the adverse reactions compared between groups.Results The total short-term effective rate in control group and observation group had no significant difference [65.3％ (47/72) vs 56.2％ (36/64)] (P ＞ 0.05).After treatment, the serum levels of MMP-2, MMP-7 and MMP-11 were significantly reduced compared with those before treatment in observation group [(4.1 ± 1.0) μg/L vs (5.0 ±1.4) μg/L, (9.4 ± 1.0) μg/L vs (16.9 ± 1.1) μg/L, (33 ± 3) μg/L vs (43 ± 4) μg/L] and control group [(4.7±1.1) μg/Lvs (5.0 ± 1.2) μg/L, (13.1 ± 1.0) μg/L vs (16.8 ± 1.2) pg/L, (38 ±3) μg/L vs (42 ±4) μg/L], moreover, they were much lower in observation group (P ＜0.05).As to the adverse reactions,the incidences of Ⅰ-Ⅱ degree neutropenia and myelosuppression in observation group were significantly lower than those in control group [20.8％ (15/72) vs 37.5％ (24/64), 16.7％ (12/72) vs 40.6％ (26/64)] (P ＜0.05), the incidences of hemoglobin reduction, thrombocytopenia, gastrointestinal reaction, hand-foot syndrome and liver function damage were not significantly different between groups.Conclusion Shenqi fuzheng injection combined with human recombinant endostatin is effective in treating advanced gastric cancer with less adverse reactions, and can decrease the levels of serum MMP-2, MMP-7, MMP-11.
Keywords：Advanced gastric cancerShenqi fuzheng injectionHuman recombinant endostatinMatrix metalloproteinases
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1786-1788 )