Effect of folic acid on homocysteine, blood pressure load and blood pressure variability in patients with type H hypertension
Qin Jingmei
Shang Xiufang
Cong Xiaorong
Abstract：Objective To observe the effect of folic acid on homocysteine (Hcy), blood pressure load (BPL) and blood pressure variability (BPV) in patients with type H hypertension.Methods One hundred and seventy-eight patients with type H hypertension were randomly divided into observation group (93 cases) receiving oral folic acid (0.8 mg) on the basis of conventional therapy and control group (85 cases) receiving conventional therapy.The treatment was lasted for 8 weeks.The Hcy level, BPL [day systolic blood pressure load (dSBPL),day diastolic blood pressure load (dDBPL), night systolic blood pressure load (nSBPL), night diastolic blood pressure load (nDBPL)] and BPV [day systolic blood pressure standard deviation (dSBPSD) , day diastolic blood pressure standard deviation (dDBPSD), night systolic blood pressure standard deviation (nSBPSD), night diastolic blood pressure standard deviation (nDBPSD)] were determined before, 4 and 8 weeks after treatment and compared between groups.The adverse reactions were also observed.Results No significant adverse reactions was found in both groups.The Hcy level was not significantly different before treatment between groups (P ＞0.05).Compared with those before treatment, the Hcy level was significantly reduced 4 and 8 weeks after treatment in observation group[(14.2 ± 5.2) , (9.7 ± 2.0) μmol/L vs (20.4 ± 8.5) μmol/L] , and was significantly lower than those in control group at the same time points [(18.4 ± 7.3), (18.6 ± 7.4) μmoL/L] (P ＜ 0.05);the Hcy level in observation group achieved the normal reference value 8 weeks after treatment.The BPL and BPV were not significantly different between groups before and after treatment (P ＞ 0.05).The dSBPL, dDBPL,nSBPL, nDBPL and dSBPSD, dDBPSD, nSBPSD, nDBPSD were all significantly decreased 4 and 8 weeks after treatment compared with those before treatment in observation group [(11.3 ± 5.2) ％, (6.3 ± 1.6) ％ vs (59.3±15.5)％;(12.4±3.5)％, (7.4±2.6)％ vs (51.4±13.7)％;(12.5±4.0)％, (6.6±1.3)％ vs (41.9±16.4)％;(9.7±3.1)％, (7.6±2.7)％ vs (39.2±11.6)％;(11.1 ±5.5), (6.8±2.0) mmHg vs (17.5 ±6.1) mmHg;(7.3 ±2.0), (3.8±1.3) mmHg vs (9.6 ±2.4) mmHg;(9.7 ±3.6), (6.5±2.3) mmHgvs (14.6±7.3) mmHg;(6.5±2.6), (2.8±1.7) mmHgvs (10.2±4.7)] and control group [(12.3±7.2)％, (8.3±1.7)％ vs (50.3±17.0)％;(10.4±3.7)％, (7.4±2.5)％ vs (42.4±12.5)％;(12.6±7.6)％, (9.6±3.0)％ vs (42.6±17.3)％;(10.0±4.2)％, (7.7±1.9)％ vs (37.6±14.7)％;(12.1 ±8.5), (9.3±2.0) mmHg vs (18.3±7.0) mmHg;(7.2±3.2), (4.4±1.5) mmHgvs (9.4±2.5) mmHg;(11.7 ±7.7), (7.3 ±2.2) mmHg vs (15.6 ±7.3) mmHg;(6.6±3.5), (3.1±2.1) mmHgvs (9.3±4.7) mmHg] (P＜0.05 or P ＜ 0.01).Conclusions Folic acid can effectively reduce the Hcy level in patients with type H hypertension, but has no significant effect on BPV and BPL.
Keywords：Type H hypertensionFolic acidHomocysteineBlood pressure loadBlood pressure variability
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1753-1757 )