Influence of percutaneous coronary intervention on collateral circulation and heart function in coronary heart disease with anterior descending lesion
Zheng Jinmin
Zhao Guiqin
Li Xin
Abstract：Objective To explore the influence of percutaneous coronary intervention (PCI) on collateral circulation and heart function in coronary heart disease with anterior descending lesion.Methods Totally 246 patients of coronary heart disease with single-vessel of anterior descending lesion confirmed by coronary angiography from March 2011 to July 2013 were enrolled and divided into collateral circulation group (105 cases) and non-collateral circulation group (141 cases);the patients in collateral circulation group were divided into collateral circulation group (58 cases), ipsilateral + contralateral collateral circulation group (26 cases), and ipsilateral collateral circulation group (21 cases).The cardiac function indicators, including left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV), B type natriuretic peptide (BNP) and red blood cell volume distribution width (RDW), were compared among groups.Results There were no significant differences between collateral circulation group and non-collateral circulation group regarding age, sex, hypertension, diabetes and smoking (P ＞ 0.05).The cardiac function before operation, 1 and 6 months after operation in collateral circulation group were as followed : LVEF (45.7 ± 9.8) ％ , (46.6 ± 0.4) ％ , (47.4 ± 0.4) ％ , LVEDV (48.36±±6.82), (48.67 ±0.28), (53.12±0.32)ml, BNP (6.32 ±1.59), (5.72±0.08), (5.59 ±0.07) ng/L, RDW (14.59 ± 1.68) ％, (13.75 ± 0.07) ％ , (13.56 ± 0.13) ％;in non-collateral circulation group was as followed : LVEF (43.6 ± 8.8) ％, (45.4 ± 0.3) ％, (46.3 ± 0.3) ％, LVEDV (48.51 ± 5.36),(48.87±0.26), (55.36 ±0.38) ml, BNP (6.39±1.27), (6.21 ±0.09), (6.05 ±0.06) ng/L, RDW (14.86 ± 1.87) ％, (14.41 ± 0.09) ％, (13.76 ± 0.12) ％.Above indicators were not significantly different between groups;the levels of LVEF, BNP, RDW 1 month after operation, the levels of LVEF, BNP, LVEDV,RDW 6 months after operation in non-collateral circulation group were significantly improved compared with those in collateral circulation group (P ＜ 0.05).The cardiac function before operation, 1 and 6 months after operation in contralateral collateral circulation group were as followed : LVEF (46.0 ± 8.9) ％ , (47.7 ± 0.4) ％ , (48.0 ±0.4)％, LVEDV (48.03 ±7.11), (48.35 ±0.33), (52.92 ±0.28) ml, BNP(6.21 ± 1.49), (5.79±0.13), (5.52 ± 0.08) ng/L, RDW (14.53 ± 1.76) ％, (13.58 ± 0.13) ％, (13.28 ± 0.15) ％;in ipsilateral +contralateral collateral circulation group was as followed : LVEF (45.6 ± 8.8) ％, (48.8 ± 0.7) ％ , (49.6 ±0.8)％, LVEDV (47.84 ±5.36), (51.96 ±0.85), (50.89 ±0.88) ml, BNP (6.13±1.85), (5.65 ±0.12), (5.31 ±0.16) ng/L, RDW (14.34 ± 1.62)％, (13.32 ±0.24)％, (13.03 ±0.23)％;in ipsilateral collateral circulation group was as followed: LVEF (40.3± 8.8)％, (45.5 ±0.8)％, (45.7 ±0.9)％,LVEDV: (50.63 ±6.76), (49.22 ±0.78), (56.12 ±0.96) ml, BNP (7.38 ± 1.52), (6.32±0.19),(5.86±0.16) ng/L, RDW (14.86±1.87)％ , (14.41 ±0.09)％ , (15.23 ±0.24)％.Above indicators were not significantly different among groups before operation (P ＞ 0.05).The levels of LVEF, BNP, RDW 1 month after operation, the levels of LVEF, BNP, LVEDV, RDW 6 months after operation were significantly different among contralateral collateral circulation group, ipsilateral + contralateral collateral circulation group and ipsilateral collateral circulation group (P ＜ 0.05).Conclusion In coronary heart disease patients with anterior descending lesion, the effect of PCI in improving heart function was better for those having collateral circulation, especially for ipsilateral and contralateral collateral circulation.
Keywords：Coronary heart diseaseAnterior descending artery lesionsPercutaneous coronary interventionCollateral circulationHeart function
Publication Date：2015-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1742-1745 )