Related risk factors and cardiac function in peri-menopausal patients with coronary heart disease
Abstract：Objective To explore the related risk factors and cardiac function in peri-menopausal patients with coronary heart disease.Methods Totally 220 peri-menopausal female patients with coronary atherosclerotic heart disease from December 2013 to December 2014 were selected as observation group;another 220 male patients with coronary heart disease were matched and selected as control group.The characteristics of coronary artery lesion, biochemical and echocardiographic indicators were compared between the two groups.Results The proportion of single vessel diseases in observation group was significantly higher than that in control group [32.7％(72/220) vs 16.8％ (37/220)], the proportion of three-vessel disease and proportion of left main coronary artery +three-vessel diseases in observation group were significantly lower than those in control group [27.7％(61/220) vs 36.8％ (81/220), 4.5 ％ (10/220) vs 12.3 ％ (27/220)] (both P ＜ 0.05);the proportion of double vessel disease had no significant difference between groups (P ＞ 0.05).The levels of total cholesterol, low density lipoprotein cholesterol, homocysteine, C reactive protein and blood uric acid in observation group were significantly lower than those in control group [(4.1 ±0.9) mmol/L vs (4.5 ± 1.2) mmol/L, (2.4 ±0.8) mmol/L vs (2.8 ±1.0) mmol/L, 10.2 (7.4, 13.6) μmol/L vs 15.3 (12.8, 20.8) μmol/L, 1.11(0.41, 2.68) mg/L vs 2.17 (0.69, 7.65) mg/L, (319 ±91) μmol/L vs (374 ± 103) μmol/L] ,the level of high density lipoprotein cholesterol was significantly higher than that in control group [(0.97 ± 0.23) mmol/L vs (0.90 ± 0.19) mmol/L] (P ＜ 0.05).Other biochemical indicators had no significant differences between groups (P ＞ 0.05).The left atrium diameter, left ventricular end-diastolic diameter, interventricular septum thickness,left ventricular posterior wall thickness in observation group were significantly smaller than those in control group [(37±7) mmvs (42±10) mm, (48±5) mmvs (50±6) mm, (9.8±3.8) mmvs (10.3±1.2) mm,(8.9 ± 1.3) mm vs (9.8 ± 1.5) mm], the left ventricular ejection fraction was significantly higher than that in control group [(63 ± 10) ％ vs (61 ± 10) ％] (P ＜ 0.05).Conclusion The peri-menopausal women with coronary heart disease have lower blood lipid level and atherosclerosis risk, better heart function and structure compared with female patients.
Keywords：Coronary artery diseasePeri-menopauseLipid metabolismInflammatory factors
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1737-1741 )