Correlation among left ventricular diastolic function, coronary stenosis degree and arterial elasticity in patients with coronary heart disease
Fu Xiaobao
Wang Hongyu
Lian Yankai
Wu Yongquan
Abstract：Objective To investigate the correlation among left ventricular diastolic function, coronary stenosis degree and arterial elasticity in patients with coronary heart disease (CHD).Methods Totally 81 patients with suspected coronary heart disease who underwent coronary angiography and left ventriculography were enrolled and divided into CHD group and control group.The carotid-femoral pulse wave velocity (cfPWV)was measured to evaluate the arterial elasticity;the left ventricular end diastolic pressure (LVEDP) was determined by invasive cardiac catheterization, and the coronary stenosis degree in CHD group was assessed by Gensini score.The correlations among LVEDP, cardiovascular risk factors, echocardiography parameters, Gensini scores and cfPWV were analyzed.Results There were 56 cases in CHD group and 25 cases in control group.In CHD group, the proportion of hypertension and diabetes, left ventricular posterior wall thickness (LVPWT) , left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), LVEDP and cfPWV were all significantly different with those in control group [73.2％ (41/56) vs 48.0％ (12/25) , 57.1％ (32/56) vs 16.0％(4/25), (0.99±0.12) cm vs (0.94±0.10) cm, (125±29) g/m2 vs (108±22) g/m2, (66±7) ％ vs (69 ±6) ％, (21±10) mmHgvs (16±5) mmHg, (8.3 ±2.1) m/s vs (7.1 ±2.0) m/s] (P＜0.05 or P＜0.01);after removing the confounding factors by Logistic analysis, there was significant difference regarding LVEDP (P ＜ 0.05), while no difference regarding cfPWV (P ＞ 0.05) between the two groups.Pearson analysis showed that LVEDP was positively correlated with Gensini score, central aortic systolic blood pressure, and interventricular septum thickness (IVST) (r =0.336, P =0.001;r =0.381, P =0.004;r =0.266, P =0.009), but it was not correlated with cfPWV (r =-0.154, P =0.258).Multiple Logistic stepwise regression analysis showed that LVEDP was positively correlated with Gensini score and central aortic systolic blood pressure (P ＜ 0.05).Conclusion Impaired left ventricular diastolic function is positively correlated with coronary stenosis degree but it is not correlated with arterial elasticity in CHD patients.
Keywords：Coronary heart diseaseLeft ventricular diastolic functionCarotid-femoral pulse wave velocity
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1733-1737 )