Influence of Tongxinluo capsule on coronary flow reserve in patients with coronary slow flow evaluated by non-invasive magnetic resonance flow measurement technique
Ge Hailong
Ma Xiaohai
Zhao Lei
Zhao Yingxin
Yang Lixia
Shi Dongmei
Zhou Yujie
Abstract：Objective To investigate the effect of Tongxinluo capsule on coronary flow reserve in patients with conorary slow flow (CSF) by magnetic resonance (MR) flow measurement technique.Methods A total of 71 patients with CSF confirmed by coronary angiography were randomly divided into observation group (38 cases)and control group (33 cases).Control group was given conventional treatment (nitrates, aspirin and Simvastatin),observation group was additionally given Tongxinluo capsule (3 capsules/time, 3 times/d) on the basis of conventional treatment.The treatment was lasted for 12 weeks.Before and 12 weeks after treatment, the MR examination and velocity encoding phase contrast (VEPC) were used to measure the flow of right coronary artery (RCA) and proximal segments of the left ascending artery (LAD);the flows at rest and stress status (intravenous dipyridamole)were determined and the coronary flow reserve (CFR) was calculated based on the forma.Results The flow and CFRs of LAD and RCA were not significantly different between groups before treatment (P ＞0.05).After 12 weeks of treatment, the flows of LAD and RCA in observation group were significantly increased compared with those before treatment at rest [(1.82 ±0.33) ml/s vs (1.35 ±0.36) ml/s, (1.75 ±0.32) ml/s vs (1.67 ±0.43) ml/s] and at stress status [(2.81 ±0.34) ml/s vs (1.83±0.32) ml/s, (3.21 ±0.25) ml/s vs (1.75 ±0.34) ml/s] (P＜0.05);the flows of LAD and RCA in control group were significantly increased compared with those before treatment at rest[(1.65 ±0.32) ml/s vs (1.39±0.35) ml/s, (1.74 ±0.38) ml/s vs (1.37 ±0.29) ml/s] (P＜0.05), but no at stress status (P ＞0.05);after 12 weeks of treatment, the flows of LAD and RCA at rest and stress status in observation group were significantly higher than those in control group (P ＜0.05).After treatment, the CFRs of LAD and RCA in observation group were significantly higher than that before treatment and that in control group [(3.36 ± 0.36)ml/s vs (2.29±0.30), (2.55 ± 0.43) ml/s, (3.11 ± 0.26) ml/s vs (2.38 ±0.36), (2.58±0.31)ml/s] (P＜0.05);the CFRs of LAD and RCA in control group were not significantly changed after treatment (P ＞ 0.05).Conclusion Tongxinluo capsule can improve the blood flow and coronary flow reserve in the patients with CSF.
Keywords：Coronary slow flowTongxinluo capsuleCoronary flow reserve
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1729-1732 )