Effect of different doses of mucosolvan on severe traumatic brain injury complicated with pulmonary infection

Cheng Weitao; Wang Ning; Chen Wenjin; Xu Yueqiao

doi:10.3760/cma.j.issn.1673-4777.2015.11.011

Abstract：Objective To investigate the effect of different doses of mucosolvan on severe traumatic brain injury complicated with pulmonary infection.Methods Sixty patients with severe traumatic brain injury complicated with pulmonary infection from January 2012 to June 2014 were randomly divided into group A, B and C (20 cases in each group).All patients were given symptomatic and supportive treatment including the intracranial pressure reduction, anti-epilepsy, anti-infection and routine care (knocking back, expectoration);group B was additionally administrated with continuous infusion of mucosolvan 600 mg/d;group C was additionally administrated with infusion of mucosolvan 30 mg/time, 2 times/d;group B and C were both given mucosolvan inhalation.After 7 and 14 days of treatment, the total effective rate, infection control rate and infection control time were compared among the three groups.Results After 14 days of treatment, the total effective rate and infection control rate in group B were significantly higher than those in group A and group C [80.0％ (16/20) vs 25.0％ (5/20), 75.0％ (15/20);80.0％ (16/20) vs 25.0％ (5/20), 75.0％ (15/20)] (P＜0.05);in group B, the infection control rate 14 days after treatment was also higher than that 7 days after treatment [80.0％ (16/20) vs 70.0％ (14/20)] (P ＜ 0.05).After 14 days of treatment, the infection control time in group B was significantly longer than that in group A and group C [(9.8 ±1.1) d vs (11.2±1.4), (10.2±1.4) d] (P＜0.05).Conclusion Large doses of mucosolvan can not only improve the overall efficiency, but also control the infection in a short time in patients with severe brain injury complicated with lung infections.