Effect of budesonide formoterol on lung function and quality of life in patients with bronchiectasis complicated with bronchial asthma
Shi Ming
Tang Youyong
Yang Zhongwei
Li Wei
Wang Zhengyan
Yuan Meichun
Abstract：Objective To explore the effect of budesonide formoterol on lung function and quality of life in patients with bronchiectasis complicated with bronchial asthma.Methods Totally 98 patients with bronchiectasis complicated with bronchial asthma from June 2012 to January 2015 were randomly divided into observation group (49 cases) given inhalation of budesonide formoterol, and control group (49 cases) given inhalation of budesonide;the treatment was lasted for 15 d.The lung function, levels of inflammatory cytokines, score of life quality and adverse reactions before and after treatment were compared between the two groups.Results After treatment, the forced expiratory volume in one second and forced vital capacity in observation group were obviously higher than those before treatment and those in control group at the same time point [(2.3 ± 0.5) L vs (1.9 ± 0.5), (2.1 ±0.7) L, (3.5 ±0.9) L vs (3.1 ±0.9), (3.2 ±0.5) L].The serum interleukin-4, tumor necrosis factor-a, score of life quality in observation group after treatment were significantly lower than those before treatment and those in control group at the same time points [(5.4 ± 2.1) ng/L vs (27.3 ± 2.4), (9.1 ± 1.9) ng/L, (20±14) ng/Lvs (124±14), (50±14) ng/L;(36±5) scoresvs (49±5), (45±5) scores] (P ＜ 0.05).During treatment, 2 patients had hoarse voice, 1 patient had dry mouth and 1 patients had palpitation in observation group;1 patients had hoarse voice, 2 patient had dry mouth in control group;all the patients recovered after symptomatic treatment;the incidence of adverse reactions had no significant difference between observation group and control group [8.2％ (4/49) vs 6.1％ (3/49)] (P ＞0.05).Conclusion Budesonide formoterol can obviously improve the lung function, airway inflammation and life quality in bronchiectasis patients complicated with bronchial asthma.
Keywords：BronchiectasisBronchial asthmaBudesonide formoterolLung functionLife quality
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1593-1595 )