Clinical research of blood pressure variability in essential hypertension patients with blood stasis syndrome
Wei Shichao
Wu Shiming
Zheng Xingyu
Luo Jiewei
Xue Feilong
Guo Miaomiao
Meng Xiaorong
Abstract：Objective To explore the blood pressure variability in essential hypertension patients with blood stasis syndrome (BSS).Methods Totally 220 patients with essential hypertension from February 2011 to February 2013, including 68 cases without BSS (non-BSS group), 67 cases with mild BSS (mild BSS group) and 85 cases with severe BSS (severe BSS group) , were enrolled.The pressure variability, circadian rhythms of blood pressure and blood pressure load were compared among groups;the independent risk factors of BSS were analyzed.Results The 24 h systolic blood pressure standard deviation (24 h SBPSD) , 24 h diastolic blood pressure standard deviation (24 h DBPSD), day systolic blood pressure standard deviation (dSBPSD), day diastolic blood pressure standard deviation (dDBPSD), night systolic blood pressure standard deviation (nSBPSD) , night diastolic blood pressure standard deviation (nDBPSD) were sequentially increased in non-BSS group, mild BSS group and severe BSS group [9.98 (8.30, 11.89), 11.68 (9.96, 13.64), 13.18 (10.66, 15.51) mmHg;8.02 (6.61,9.31), 8.37 (6.97, 10.13), 9.36 (7.75, 10.94) mmHg;9.22 (7.83, 10.91), 11.43 (9.52, 13.89),13.14 (9.90, 15.54) mmHg;7.42 (6.29, 8.66), 8.32 (6.80, 9.96), 9.00 (7.29, 11.25) mmHg;8.04(6.38, 10.20), 9.77 (8.03, 11.84), 12.22 (9.65, 14.42) mmHg;(7.1±2.5), (7.4±2.6), (8.6±3.2) mmHg];the 24 h SBPSD, dSBPSD, nSBPSD were significantly different between one and the other group, the 24 h DBPSD and nDBPSD in severe BSS group were significantly higher than those in non-BSS group and mild BSS group, the dDBPSD in mild and severe BSS group was significantly higher than in non-BSS group (P ＜ 0.05).The proportion of spoon type circadian rhythms in non-BSS group was significantly higher than that in mild and severe BSS group [27.9％ (19/68) vs 6.0％ (4/67), 7.1％ (6/85)] (P ＜0.01).The 24 h systolic blood pressure load (24 h SBPL) , day systolic blood pressure load (dSBPL) and night systolic blood pressure load (nSBPL) were sequentially increased in non-BSS group, mild BSS group and severe BSS group [12.31％ (0.00％, 39.80％), 20.60％ (5.71％, 52.50％), 34.40％ (21.70％, 70.70％);6.56％ (0.00％,32.14％), 17.86％ (3.13％, 37.50％), 27.80％ (12.70％, 65.35％);18.20％ (0.00％, 65.93％),36.40％ (12.50％, 75.00％), 57.14％ (26.79％, 87.50％)];the 24 h SBPL and dSBPL in severe BSS group were significantly higher than those in non-BSS group and mild BSS group, the nSBPL was significantly different between one and the other group (P ＜ 0.05).After adjustment of relative factors, the nSBPSD and nDBPRR were independent risk factors of BSS [odds ratio (OR) =1.412, 95％ confidence interval (CI) : 1.096-1.820, P ＜0.01;OR =1.211,95％ CI: 1.062-1.381, P ＜0.01].Conclusion Increased blood pressure variability is an independent risk factor of BSS in essential hypertension
Keywords：Essential hypertensionBlood pressure variabilityBlood stasis syndrome
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1569-1573 )