Level and clinical significance of serum 25-hydroxyvitamin D in patients with rheumatoid arthritis

Liao Hua; Pan Lili; Gao Na; Wan Jin; Wang Tian

doi:10.3760/cma.j.issn.1673-4777.2015.10.020

Abstract：Objective To evaluate the level and clinical siguificance of serum 25-hydroxyvitamin D in patients with rheumatoid arthritis (RA).Methods Totally 108 untreated RA patients (RA group) and 49 healthy people (control group) from January 2014 to January 2015 were enrolled.According to the disease activity score in 28 joints (DAS28),patients in RA group were divided into remission stage group (＜ 2.6 scores,42 cases) and active stage group (＞3.2 scores,66 cases).The levels of serum 25-(OH)-D were measured and compared among groups.The correlations between 25-(OH)-D level and relative indicators were analyzed.Results The level of serum 25-(OH)-D in RA group was significantly lower than that in control group [(13 ±7) μg/L vs (26 ± 5) μg/L] (P ＜ 0.01).There were negative correlations between serum 25-(OH)-D level and C reactive protein (CRP),erythrocyte sedimentation rate (ESR),DAS28 score in RA group (r =-0.361,r =-0.280,r =-0.275,P ＜ 0.01).The level of serum 25-(OH)-D was not significantly different between remission group and active group (P ＞0.05).The serum 25-(OH)-D level was negatively correlated with CRP,ESRandDAS28 score (r=-0.467,r=-0.245,r=-0.499,P＜0.05) in active stage group but not in remission stage group (P ＞0.05).In active stage group,the 25-(OH)-D levels in males and females were not significantly different;it was negatively correlated with CRP,ESR,DAS28 in females (r =-0.529,r =-0.373,r=-0.572,P＜0.05),but not in males in RA patients (P＞0.05).Conclusion The 25-(OH)-D level in serum is reduced in patients with RA and it is negatively correlated with disease activity,especially in female patients;serum 25-(OH)-D level can be as a marker of monitoring the disease activity in RA patients.