Distribution of hepatitis B virus genotype/subgenotype and analysis of clinical outcomes in Shanxi province

Wang Miao; Hu Yanfang; Lu Lu; Wang Qinying

doi:10.3760/cma.j.issn.1673-4777.2015.10.018

Abstract：Objective To investigate the distribution of hepatitis B virus (HBV) genotype and subgenotype in Shanxi province,and to analyze the clinical outcomes of patients infected with different genotype and subgenotype of HBV.Methods Totally 266 patients of chronic HBV infection from February 2013 to July 2014 were enrolled,including 159 cases of chronic hepatitis B (hepatitis group),89 cases of cirrhosis (cirrhosis group) and 18 cases of hepatocarcinoma (hepatocarcinoma group).The genotype and subgenotype of HBV were determined by Nested polymerase chain reaction (ntPCR).The distribution of the genotype and subgenotype of HBV and the clinical outcomes were analyzed.Results In 266 cases,32 (12.0％) were found to be genotype B (all subgenotype B2);229 (86.1％) were genotype C (all subgenotype C2);5 (1.9％) were genotype B/C.Compared with the patients with genotype B (subgenotype B2) HBV infection,the patients with genotype C (subgenotype C2) had higher proportions of male,older age and longer duration [66.8％ (153/229) vs 46.9％ (15/32),43.00 years (32.00 years,51.00 years) vs 29.00 years (25.00 years,38.25 years),4.00 years (2.00 years,9.00 years) vs 2.00 years (2.00 years,2.75 years)] (P ＜ 0.05).In patients with genotype B (subgenotype B2) HBV infection,there were 81.3％ (26/32) of hepatitis and 18.8％ (6/32) of cirrhosis;in patients with genotype C (subgenotype C2) HBV infection,there were 55.9％ (128/229) of hepatitis,36.2％ (83/229) of cirrhosis and 7.9％ (18/229) of hepatocarcinoma,showing significant differences among different genotypes (x2 =8.09,P =0.02).Conclusions There are genotype B (subgenotype B2),genotype C (subgenotype C2) and genotype B/C HBV in patients with chronic HBV infection infection in Shanxi province.The genotype C (subgenotype C2) HBV infection is predominant with poor clinical outcomes.