Effect of calcium dobesilate on C reactive protein, neuropeptide Y and cortisol in patients with cerebral infarction

Chi Yulian; Zhang Yong

doi:10.3760/cma.j.issn.1673-4777.2015.10.012

Abstract：Objective To explore the effect of calcium dobesilate on C reactive protein (CRP),neuropeptide Y (NPY) and cortisol in patients with cerebral infarction (CI).Methods Totally 80 patients with CI from Junuary 2011 to November 2014 were enrolled and randomly divided into control group (40 cases) receiving conventional therapy and observation group (40 cases) receiving conventional therapy ± calcium dobesilate (500 mg/time,3 times/d,oral).The treatment lasted for 2 weeks.The changes of disease severity,national institute of health stroke scale (NIHSS),barthel index (BI),CRP,NPY and cortisol were compared between the two gruops.Results The infarction volume was not significantly different between observation group and control group[(7 ±4) cm3 vs (7 ±4) cm3,P ＞0.05].There were 11 eases of severe infarction,17 cases of moderate infarction and 12 cases of mild infarction in observation group;there were 10 cases of severe infarction,18 cases of moderate infarction and 12 cases of mild infarction in control group;no significant differences were found between the two groups (Z =1.423,P ＞ 0.05).Before treatment,NIHSS and BI in observation group were both not significantly different compared with those in control group (P ＞ 0.05);after 2 weeks of treatment,NIHSS was significant lower than pretreatment and control group and BI was significant higher than pretreatment and control group [(11.4±3.2) scores vs (19.6±5.1),(15.1 ±2.7) scores,(74±12) scores vs (48±18),(62± 7) scores] (P ＜ 0.05).Before treatment,CRP,NPY and cortisol were all not significantly different between observation group and control group [(4.1 ±0.6) mg/L vs (4.1 ±0.7) mg/L,(270 ±42) ng/L vs (272 ±42) ng/L,(421 ± 45) μg/L vs (420 ± 45) μμg/L] (P ＞ 0.05);after 1 and 2 weeks of treatment,above indices were significantly lower in observation group compared with those in control group [1 week:(4.7 ±0.4) mg/L vs (5.5 ±0.5) mg/L,(309±45) ng/L vs (357 ±40) ng/L,(216 ±57) μg/L vs (298 ±42) μg/L;2 weeks:(3.2 ±0.5) mg/L vs (3.7 ±0.3) mg/L,(98 ± 38) ng/L vs (122 ±40) ng/L,(174 ± 32) μg/L vs (213 ±27) μg/L];after 2 weeks of treatment,above indices were all significantly tower than pretreatment in both groups (P ＜ 0.05).Conclusion Calcium dobesilate can effectively ameliorate the NIHSS and BI in patients with cerebral infarction;it can decrease the CRP,NYP and cortisol levels.