Analysis of clinical features of Takayasu's arteritis complicated with pulmonary arterial hypertension
Wan Jin
Wang Tian
Pan Lili
Ci Weiping
Liao Hua
Abstract：Objective To explore the clinical features of Takayasu's arteritis (TA) complicated with pulmonary arterial hypertension (PAH).Methods Clinical manifestations,lab data and imaging findings of 85 TA inpatients from January 2004 to January 2014 were retrospectively analyzed.The clinical data were compared between patients with PAH and without PAH.Results Seven patients (8.2％) had PAH,including 6 females and 1 male.Seven patients had pulmonary artery involved but without PAH and their onset age and time of diagnosis were significantly different from those TA patients with PAH [(33 ±7) years vs (25 ±3) years,(19 ±8) months vs (55 ±41) months] (P ＜0.05).In patients with PAH,4 cases had chest/back pain and anhelation after exercise as initial symptoms;the involved vessels were mainly subclavian artery (5 cases),pulmonary artery (4 cases) and aorta (4 cases);according to angiographic classification,1 case was type Ⅱ,2 cases were type Ⅲ,1 case was type Ⅱ + Ⅳ,2 cases were type Ⅲ + Ⅳ,1 case was type Ⅰ + Ⅳ;6 cases had pulmonary stenosis;6 cases had valve lesions;the average pulmonary arterial systolic pressure was (62 ± 22) mmHg.Regarding drug treatment,single corticosteroid treatment was given in 2 cases;corticosteroid combined with cyclophosphamide,asprin and leflunomide were given in 1 case;tripterygium combined with asprin were given in 1 case;single antiplatelet therapy was given in 3 cases;the level of C reactive protein and erythrocyte sedimentation rate were both abnormally increased [(16 ±4) mg/L,(45 ±7) mm/1 h].Compared with patients without PAH,patients with PAH were more prone to anhelation after exercise,weakness,and there were more involvement of pulmonary artery,ascending aorta and aortic arch but less dizziness [57.1％ (4/7) vs 20.5％ (16/78),71.4％ (5/7) vs 34.6％ (27/78),57.1％ (4/7)vs9.0％ (7/78),28.6％ (2/7)vs9.0％ (7/78),28.6％ (2/7)vs3.8％(3/78),0.0％ (0/7) vs 64.1％ (50/78)] (P＜0.05).Conclusion PAH is a serious complication of TA when the pulmonary arterial is involved;the pulmonary artery pressure should be paid attention in those with anhelation after exercise,weakness,and involvement of pulmonary artery,ascending aorta and aortic arch;active treatment of the primary disease helps reduce the pulmonary artery systolic pressure.
Keywords：Takayasu's arteritisPulmonary arterial hypertensionClinical feature
Publication Date：2015-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1435-1438 )