Effect of high-loading-dosage of rosuvastatin and tirofiban before percutaneous coronary intervention on myocardial reperfusion injury
Zhou Fazhan
Song Zhaofeng
Liu Jifang
Zhang Huanyi
Yin Luhua
Abstract：Objective To explore the effect of high-loading-dosage of rosuvastatin and tirofiban on myocardial reperfusion injury and prognosis in patients with acute myocardial infarction (AMI) undergoing emergency percutaneous coronary intervention (PCI).Methods Totally 85 patients with AMI undergoing emergency PCI from April 2012 to January 2014 were enrolled and randomly divided into observation group (43 cases) given high-loading-dosage of rosuvastatin (20 mg,oral) and tirofiban [10 μg/kg bolus,then 0.15 μg/(kg · min) infusion for 36 h] before operation,rosuvastatin (10 mg/d) after operation,and control group (42 cases) given rosuvastatin 10 mg/d after operation.The thrombolysis in myocardial infarction (TIMI) flow grade was assessed by coronary angiography at the end of PCI;the plasma concentrations of soluble intercellar adhesion molecules 1 (sICAM-1),soluble vascular cell adhesion molecule l (sVCAM-1) and high sensitivity C reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay (ELISA) before and after PCI;the postoperative major adverse cardiac events 6 months after PCI,including recurrence of angina pectoris,myocardial infarction and death,were recorded and compared between the two groups.Results The proportion of TIMI grade 3 in observation group was significantly higher than that in control group [79.1％ (34/43) vs 50.0％ (21/42)] (P ＜ 0.01);24 h after PCI,the levels of sICAM-1,sVCAM-1 and hs-CRP were significantly lower than those in control group [(24.2 ± 2.3) μg/L vs (37.2±3.3) μg/L,(26.2±2.9) μg/L vs (43.3±3.8) μg/L,(8.2±5.0) mg/L vs (10.9±4.7) mg/L] (P ＜ 0.05).Six months after PCI,the incidences of angina pectoris recurrence and myocardial infarction in observation group were not significantly different from those in control group (P ＞ 0.05);no death occurred in both groups.Conclusion Application of high-loading-dose of rosuvastatin and tirofiban before operation can decrease the myocardial tissue perfusion injury and improve the prognosis in AMI patients undergoing emergency PCI.
Keywords：RosuvastatinTirofibanMyocardial infarctionPercutaneous coronary interventionMyocardial reperfusion injury
Publication Date：2015-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1413-1417 )